Mosquito Control Workers in Malaysia: Is Lifetime Occupational Pesticide Exposure Associated With Poorer Neurobehavioral Performance?
Background Use of pesticides has been linked to neurobehavioral deficits among exposed workers. In Malaysia, organophosphate and pyrethroid pesticides are commonly used to control mosquito-borne diseases. Objectives This study aims to assess workers' lifetime occupational pesticide exposure and exam...
| Publicado en: | Annals of Work Exposures & Health Vol. 66; no. 8; pp. 1044 - 1056 |
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| Autores principales: | , , , |
| Formato: | questions and answers research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159695752&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159695752 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23987308 KJ1E jtl: Annals of Work Exposures & Health issn: 23987308 maglogo: N pubinfo: dt: Oct2022 vid: 66 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 159695752 159695752 159695752 10.1093/annweh/wxac038 159695752 ppf: 1044 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mosquito Control Workers in Malaysia: Is Lifetime Occupational Pesticide Exposure Associated With Poorer Neurobehavioral Performance? aug: au: Yusof, Muhammad Zubir Cherrie, John W Samsuddin, Niza Semple, Sean affil: Department of Community Medicine, Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia , Bandar Indera Mahkota Campus, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang Darul Makmur , Malaysia sug: subj: Vector Borne Diseases Prevention and Control Occupational Health Malaysia Neurobehavioral Manifestations Occupational Exposure Skin Diseases Risk Factors Pesticides Adverse Effects Chemical Hazard Release Adverse Effects Human Cross Sectional Studies Questionnaires Interviews Malaysia Confidence Intervals Memory Evaluation Organophosphorus Compounds Adverse Effects Adult Blue Collar Workers Adult: 19-44 years ab: Background Use of pesticides has been linked to neurobehavioral deficits among exposed workers. In Malaysia, organophosphate and pyrethroid pesticides are commonly used to control mosquito-borne diseases. Objectives This study aims to assess workers' lifetime occupational pesticide exposure and examine the relationship with neurobehavioral health. Methods A cross-sectional study was conducted on 158 pesticide-exposed and 176 non-exposed workers. To collect historical exposure and job tasks, a questionnaire and an occupational history interview were used. Pesticide exposure was measured in a subgroup of workers via inhalation and skin contact. The total pesticide intake of each worker was assessed using inhalation and dermal exposure models. CANTAB® computerised neurobehavioral performance assessments were used. Results The participants' mean age was 31 (8) years. Pirimiphos-methyl (median = 0.569 mg/m3, Interquartile range [IQR] = 0.151, 0.574) and permethrin (median = 0.136 mg/m3, IQR = 0.116, 0.157) had the highest measured personal inhalation concentrations during thermal spraying. The estimated total lifetime pesticide intake for exposed workers ranged from 0.006 g to 12800 g (median = 379 g and IQR = 131, 794 g). Dermal exposure was the predominant route of pesticide intake for all workers. Compared to controls, workers with high lifetime pesticide intake had lower Match to Sample Visual (adjusted B = −1.4, 95% Confidence Interval (CI) = −2.6, 0.1), Spatial Recognition Memory (adjusted B = −3.3, 95% CI = −5.8, 0.8), Spatial Span (SSP) (adjusted B = −0.6, 95% CI = −0.9, 0.3) scores. Workers with low pesticide intake performed worse than controls (adjusted B = −0.5, 95% CI = −0.8, −0.2) in the SSP test, but scored higher in the Motor Screening test (adjusted B = 0.9, 95% CI = 0.1, 1.6). Higher Paired Associates Learning test scores were observed among higher (adjusted B = 7.4, 95% CI = 2.3, 12.4) and lower (adjusted B = 8.1, 95% CI = 3, 13.2) pesticide intake groups. There was no significant difference between the Reaction Time and Pattern Recognition Memory tests with lifetime pesticide intake after adjusting for confounders. Conclusion Pesticide exposure has been linked to poorer neurobehavioral performance. As dermal exposure accounts for a major fraction of total intake, pesticide prevention should focus on limiting dermal exposure. pubtype: Academic Journal doctype: questions and answers research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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