Blood flow and perfusion lateralization in border zone infarct using 4D flow and arterial spin labeling.
Purpose: Hemodynamics may play an important role in border zone infarct (BZI), but macroscopic and microscopic hemodynamics of BZI still remain unclear. This study aims to investigate arterial flow and tissue perfusion differences between BZI and non-BZI in patients with unilateral middle cerebral a...
| Publicado en: | Neuroradiology Vol. 64; no. 11; pp. 2145 - 2153 |
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| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159724031&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159724031 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Nov2022 vid: 64 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159724031 159724031 159724031 10.1007/s00234-022-02967-0 159724031 ppf: 2145 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Blood flow and perfusion lateralization in border zone infarct using 4D flow and arterial spin labeling. aug: au: Chen, Wenwen Song, Xiaowei Chen, Shuo Chen, Zhensen Fu, Mingzhu Wei, Chenming Zheng, Zhuozhao Wu, Jian Li, Rui affil: Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China sug: subj: Ischemic Stroke Pathology Cerebral Infarction Pathology Middle Cerebral Artery Pathology Hemodynamics Evaluation Tissue Perfusion Evaluation Cerebrovascular Circulation Evaluation Magnetic Resonance Imaging Methods Neuroradiography Human Stroke Patients Comparative Studies Middle Age Aged Male Female Descriptive Statistics Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Purpose: Hemodynamics may play an important role in border zone infarct (BZI), but macroscopic and microscopic hemodynamics of BZI still remain unclear. This study aims to investigate arterial flow and tissue perfusion differences between BZI and non-BZI in patients with unilateral middle cerebral artery (MCA) territory infarcts. Methods: Subacute ischemic stroke patients with unilateral infarcts at MCA territory were included. Imaging protocols included 4D flow, ASL (arterial spin labeling), and routine clinical brain MRI scan. A total of 56 patients (56.1 ± 11.9 years, 39 male) were included and divided as BZI (n = 26) and non-BZI (n = 30). BZI was further subdivided as cortical BZI (CBZI, n = 9), internal BZI (IBZI, n = 11), and mixed BZI (n = 6). Average blood flow (Flowavg), regional average cerebral blood flow (CBFavg) were compared between infarct and contralateral sides to test hemodynamic lateralization. Flow-index and CBF-index (infarct sides/contralateral sides) were compared between groups and subgroups. Results: Flowavg and CBFavg showed significant lateralization in both BZI and non-BZI as well as CBZI and IBZI. Flow-index (0.51 ± 0.37 vs. 0.87 ± 0.36, p < 0.01) and CBF-index (0.70 ± 0.21 vs. 0.90 ± 0.19, p < 0.01) were significantly different between BZI and non-BZI but were not significantly different between CBZI and IBZI. Conclusion: In summary, hemodynamic lateralization can occur in subacute stroke patients with BZI and non-BZI and the one that occurs in BZI tends to be more severe in view of arterial flow and tissue perfusion. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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