Prognostic role of iodine values for gastric cancer after neoadjuvant chemotherapy: a strong independent prognostic factor.
PURPOSE We aimed to systematically explore the value of iodine values calculated from dual-energy computed tomography (DECT) as potential prognostic factors for locally advanced gastric cancer (LAGC) patients undergoing neoadjuvant chemotherapy (NAC). METHODS Eighty-five LAGC patients were examined...
| Publicado en: | Diagnostic & Interventional Radiology Vol. 28; no. 5; pp. 388 - 396 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Galenos Yayinevi Tic. LTD. STI
Sep2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159741417&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159741417 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13053825 39NM jtl: Diagnostic & Interventional Radiology issn: 13053825 maglogo: N pubinfo: dt: Sep2022 vid: 28 iid: 5 pid: 28155 pub: Galenos Yayinevi Tic. LTD. STI artinfo: ui: 159741417 159741417 NLM35997476 10.5152/dir.2022.201007 NLM35997476 159741417 ppf: 388 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Prognostic role of iodine values for gastric cancer after neoadjuvant chemotherapy: a strong independent prognostic factor. aug: au: Yang Zhang Junfa Chen Fei Yuan Benyan Zhang Bei Ding Huan Zhang Zhang, Yang Chen, Junfa Yuan, Fei Zhang, Benyan Ding, Bei Zhang, Huan affil: Cancer Center, Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China sug: subj: Stomach Neoplasms Drug Therapy Stomach Neoplasms Pathology Iodine Therapeutic Use Stomach Neoplasms Prognosis Retrospective Design Survival Analysis Neoadjuvant Therapy Scales ab: PURPOSE We aimed to systematically explore the value of iodine values calculated from dual-energy computed tomography (DECT) as potential prognostic factors for locally advanced gastric cancer (LAGC) patients undergoing neoadjuvant chemotherapy (NAC). METHODS Eighty-five LAGC patients were examined using DECT before and after NAC and were divided into responders and non-responders based on the tumor regression grade (TRG). The iodine values, including portal- and delayed-phase iodine uptake (IU-p and IU-d, mg/ml) and total iodine uptake (TIU-p and TIU-d, mg) were acquired. Correlations between the reduction ratios of iodine values and TRG were analyzed. The diagnostic performance of parameters for differentiating responders from non-responders was calculated. Kaplan-Meier method was used for survival analysis. RESULTS The reduction ratios of total iodine uptake (%△TIU-p and %△TIU-d) were significantly correlated with TRG (p < 0.001). The ypN stage, %△TIU-p and %△TIU-d were significant factors influencing PFS (p < 0.050). A value of %△TIU-d≤62.19% was associated with negative prognosis [relative risk (RR):2.103; P = 0.021], as was ypN stage (RR:4.250; p = 0.003). CONCLUSION Iodine values (especially the TIU) are noninvasive quantitative parameters that are potentially helpful for evaluating the treatment response and survival prognosis of LAGC after NAC. %△TIU-d represents a strong independent prognostic factor, increasing preoperative risk assessment performance. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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