Childhood trauma is associated with social anhedonia and brain gray matter volume differences in healthy subjects.
The present study tested the effects of childhood trauma (CT) on trait social anhedonia (SA) and on gray matter volume (GMV) and explored the possible relationships among CT, SA and brain GMV. Forty-three healthy individuals with experience of moderate-to-severe CT and sixty-eight individuals with n...
| Publicado en: | Brain Imaging & Behavior Vol. 16; no. 5; pp. 1964 - 1973 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159758557&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159758557 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Oct2022 vid: 16 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159758557 157931931 159758557 NLM35819706 10.1007/s11682-022-00666-1 NLM35819706 159758557 ppf: 1964 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Childhood trauma is associated with social anhedonia and brain gray matter volume differences in healthy subjects. aug: au: Fan, Jie Liu, Wanting Xia, Jie Gao, Feng Meng, Chuyi Han, Yan Zhou, Huan Yi, Jinyao Tan, Changlian Zhu, Xiongzhao affil: Medical Psychological Center, the Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China sug: subj: Gray Matter Magnetic Resonance Imaging Brain Research Subjects Anhedonia Social Readjustment Rating Scale ab: The present study tested the effects of childhood trauma (CT) on trait social anhedonia (SA) and on gray matter volume (GMV) and explored the possible relationships among CT, SA and brain GMV. Forty-three healthy individuals with experience of moderate-to-severe CT and sixty-eight individuals with no or low CT participated in the present study. Trait SA was evaluated using the Revised Social Anhedonia Scale. GMV was measured using voxel-based morphometry. Participants with moderate-to-severe CT had elevated trait SA, as well as brain volumetric differences in left inferior parietal lobule (IPL), left precuneus, right insula, left superior temporal gyrus, and left middle occipital gyrus extending into middle temporal gyrus relative to participants with no or low level of CT. CT was also found to be positively correlated with GMV in right dorsolateral prefrontal cortex (DLPFC) and bilateral precuneus. Partial mediation effect of GMV in left IPL and right DLPFC on the relationship between CT and trait SA was significant. These findings suggest that CT may have effects on trait SA and on GMV of widespread brain regions. GMV differences in DLPFC and left IPL may mediate the effect of CT on trait SA, although this needs to be verified by future longitudinal studies. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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