Nested U-Net for Segmentation of Red Lesions in Retinal Fundus Images and Sub-image Classification for Removal of False Positives.

Diabetic retinopathy is a pathological change of the retina that occurs for long-term diabetes. The patients become symptomatic in advanced stages of diabetic retinopathy resulting in severe non-proliferative diabetic retinopathy or proliferative diabetic retinopathy stages. There is a need of an au...

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Publicado en:Journal of Digital Imaging Vol. 35; no. 5; pp. 1111 - 1120
Autores principales: Kundu, Swagata, Karale, Vikrant, Ghorai, Goutam, Sarkar, Gautam, Ghosh, Sambuddha, Dhara, Ashis Kumar
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Oct2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Oct2022
      vid: 35
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10278-022-00629-4
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        atl: Nested U-Net for Segmentation of Red Lesions in Retinal Fundus Images and Sub-image Classification for Removal of False Positives.
      aug:
        au:
          Kundu, Swagata
          Karale, Vikrant
          Ghorai, Goutam
          Sarkar, Gautam
          Ghosh, Sambuddha
          Dhara, Ashis Kumar
        affil: Electrical Engineering Department, National Institute of Technology Durgapur, 713209, Durgapur, India
      sug:
        subj:
          False Positive Results
          Retina
          Image Processing, Computer Assisted Methods
          Diabetic Retinopathy Diagnosis
          Image Interpretation, Computer Assisted Methods
          Neural Networks (Computer) Utilization
          Human
          False Negative Results
          Sensitivity and Specificity
          Descriptive Statistics
          Algorithms
          Deep Learning
          Decision Support Systems, Clinical
          Semantics
      ab: Diabetic retinopathy is a pathological change of the retina that occurs for long-term diabetes. The patients become symptomatic in advanced stages of diabetic retinopathy resulting in severe non-proliferative diabetic retinopathy or proliferative diabetic retinopathy stages. There is a need of an automated screening tool for the early detection and treatment of patients with diabetic retinopathy. This paper focuses on the segmentation of red lesions using nested U-Net Zhou et al. (Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support, Springer, 2018) followed by removal of false positives based on the sub-image classification method. Different sizes of sub-images were studied for the reduction in false positives in the sub-image classification method. The network could capture semantic features and fine details due to dense convolutional blocks connected via skip connections in between down sampling and up sampling paths. False-negative candidates were very few and the sub-image classification network effectively reduced the falsely detected candidates. The proposed framework achieves a sensitivity of 88.79 % , precision of 71.50 % , and F1-Score of 79.21 % for the DIARETDB1 data set Kalviainen and Uusutalo (Medical Image Understanding and Analysis, Citeseer, 2007). It outperforms the state-of-the-art networks such as U-Net Ronneberger et al. (International Conference on Medical Image Computing and Computer-Assisted Intervention, Springer, 2015) and attention U-Net Oktay et al. (Attention u-net: Learning where to look for the pancreas, 2018).
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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