Association between acute kidney injury and brain injury on term-equivalent age brain magnetic resonance imaging in very preterm infants.
Background: This study aimed to investigate the relationship between acute kidney injury (AKI) in the first 2 weeks of life and brain injury on term-equivalent age magnetic resonance imaging in very preterm infants. Methods: We included 116 infants with a birth weight of < 1500 g who were born at th...
| Published in: | Pediatric Nephrology Vol. 37; no. 12; pp. 3235 - 3243 |
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| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Dec2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159793299&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159793299 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Dec2022 vid: 37 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159793299 156040640 159793299 159793299 10.1007/s00467-022-05534-0 159793299 ppf: 3235 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between acute kidney injury and brain injury on term-equivalent age brain magnetic resonance imaging in very preterm infants. aug: au: Al-Mouqdad, Mountasser M. Jamjoom, Dima Z. Abdalgader, Ayman T. Ameen, Waleed S. Khalil, Thanaa M. Asfour, Yasmeen S. Al-Anazi, Maha R. Asfour, Suzan S. affil: Neonatal Intensive Care, Hospital of Paediatrics, King Saud Medical City, Al Imam Abdul Aziz Ibn Muhammad Ibn Saud, 12746, Riyadh, Saudi Arabia sug: subj: Infant, Premature Kidney Failure, Acute Complications Brain Injuries Risk Factors Risk Assessment Magnetic Resonance Imaging Human Univariate Statistics Infant Cerebellum Pathology Infant: 1-23 months ab: Background: This study aimed to investigate the relationship between acute kidney injury (AKI) in the first 2 weeks of life and brain injury on term-equivalent age magnetic resonance imaging in very preterm infants. Methods: We included 116 infants with a birth weight of < 1500 g who were born at the King Saud Medical City at ≤ 32 gestational weeks. They were admitted to the neonatal intensive care unit and underwent term-equivalent age and pre-discharge brain magnetic resonance imaging. A negative binomial with generalized linear models and a robust variance estimator (Huber–White) was applied for univariate relative risk analysis. The Kidokoro score was then used to determine the effect of AKI on brain morphology and growth at term-equivalent age. Results: Sixty-eight (64.2%) infants had developed an AKI in the first 2 weeks of life. AKI was significantly associated with cerebellum signal abnormalities, cerebellar volume reduction, and a high total cerebellum score (P = 0.04, P < 0.001, P < 0.001, respectively). Conclusions: AKI in the first 2 weeks of life is associated with brain insult, especially in the cerebellum. More well-designed studies are required to investigate the association and impact of AKI on the central nervous system. A higher resolution version of the Graphical abstract is available as Supplementary information pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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