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Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis.

Cardiovascular diseases represent one of the first causes of death around the world, and atherosclerosis is one of the first steps in the development of them. Although these problems occur mainly in elderly, the incidence in younger people is being reported, and an undetermined portion of patients w...

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Published in:BioMed Research International Vol. 2022; pp. 1 - 17
Main Author: Francisco, Avilés-Jiménez
Format: pictorial review tables/charts Journal Article
Published: Wiley-Blackwell 10/22/2022
Online Access:View this record in EBSCOhost
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      jtl: BioMed Research International
      issn: 23146133
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      dt: 10/22/2022
      vid: 2022
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        159859641
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        10.1155/2022/9943158
        159859641
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        atl: Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis.
      aug:
        au: Francisco, Avilés-Jiménez
        affil: Unidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Pediatría. Centro Médico Nacional Siglo XXI. IMSS, Ciudad de México, Mexico
      sug:
        subj:
          Atherosclerosis Risk Factors
          Helicobacter Infections Complications
          Intestines Pathology
          Gut Microbiota Analysis
          Risk Assessment
          Helicobacter Pylori Analysis
          Systemic Inflammatory Response Syndrome
          Endothelial Cells
          Cytotoxins
          Lipids Metabolism
      ab: Cardiovascular diseases represent one of the first causes of death around the world, and atherosclerosis is one of the first steps in the development of them. Although these problems occur mainly in elderly, the incidence in younger people is being reported, and an undetermined portion of patients without the classic risk factors develop subclinical atherosclerosis at earlier stages of life. Recently, both the H. pylori infection and the intestinal microbiota have been linked to atherosclerosis. The mechanisms behind those associations are poorly understood, but some of the proposed explanations are (a) the effect of the chronic systemic inflammation induced by H. pylori, (b) a direct action over the endothelial cells by the cytotoxin associated gene A protein, and (c) alterations of the lipid metabolism and endothelial dysfunction induced by H. pylori infection. Regarding the microbiota, several studies show that induction of atherosclerosis is related to high levels of Trimethylamine N-oxide. In this review, we present the information published about the effects of H. pylori over the intestinal microbiota and their relationship with atherosclerosis and propose a hypothesis to explain the nature of these associations. If H. pylori contributes to atherosclerosis, then interventions for eradication and restoration of the gut microbiota at early stages could represent a way to prevent disease progression.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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