Non-invasive Hemoglobin Measurement Predictive Analytics with Missing Data and Accuracy Improvement Using Gaussian Process and Functional Regression Model.

Recent use of noninvasive and continuous hemoglobin (SpHb) concentration monitor has emerged as an alternative to invasive laboratory-based hematological analysis. Unlike delayed laboratory based measures of hemoglobin (HgB), SpHb monitors can provide real-time information about the HgB levels. Real...

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Publicado en:Journal of Medical Systems Vol. 46; no. 11; pp. 1 - 11
Autores principales: Man, Jianing, Zielinski, Martin D., Das, Devashish, Sir, Mustafa Y., Wutthisirisart, Phichet, Camazine, Maraya, Pasupathy, Kalyan S.
Formato: equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Nov2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Nov2022
      vid: 46
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10916-022-01854-8
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        atl: Non-invasive Hemoglobin Measurement Predictive Analytics with Missing Data and Accuracy Improvement Using Gaussian Process and Functional Regression Model.
      aug:
        au:
          Man, Jianing
          Zielinski, Martin D.
          Das, Devashish
          Sir, Mustafa Y.
          Wutthisirisart, Phichet
          Camazine, Maraya
          Pasupathy, Kalyan S.
        affil: School of Mechanical Engineering, Institute of Industrial and Intelligent System Engineering, Beijing Institute of Technology, Beijing, China
      sug:
        subj:
          Hemoglobins Analysis
          Monitoring, Physiologic Methods
          Monitoring, Physiologic Equipment and Supplies
          Prediction Models
          Models, Statistical
          Validity
          Human
          Minnesota
          Female
          Male
          Adult
          Middle Age
          Aged
          Retrospective Design
          Oximetry Equipment and Supplies
          Hemoglobinometry
          Hemorrhage
          Factor Analysis
          Regression
          Correlation Coefficient
          Descriptive Statistics
          Funding Source
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Aged: 65+ years
          Female
          Male
      ab: Recent use of noninvasive and continuous hemoglobin (SpHb) concentration monitor has emerged as an alternative to invasive laboratory-based hematological analysis. Unlike delayed laboratory based measures of hemoglobin (HgB), SpHb monitors can provide real-time information about the HgB levels. Real-time SpHb measurements will offer healthcare providers with warnings and early detections of abnormal health status, e.g., hemorrhagic shock, anemia, and thus support therapeutic decision-making, as well as help save lives. However, the finger-worn CO-Oximeter sensors used in SpHb monitors often get detached or have to be removed, which causes missing data in the continuous SpHb measurements. Missing data among SpHb measurements reduce the trust in the accuracy of the device, influence the effectiveness of hemorrhage interventions and future HgB predictions. A model with imputation and prediction method is investigated to deal with missing values and improve prediction accuracy. The Gaussian process and functional regression methods are proposed to impute missing SpHb data and make predictions on laboratory-based HgB measurements. Within the proposed method, multiple choices of sub-models are considered. The proposed method shows a significant improvement in accuracy based on a real-data study. Proposed method shows superior performance with the real data, within the proposed framework, different choices of sub-models are discussed and the usage recommendation is provided accordingly. The modeling framework can be extended to other application scenarios with missing values.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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