Modeling, Simulation and Validation of Alteration in Blood Flow and Regional Oxygenation Under Arterial Occlusion.
The paper presents the mathematical modeling along with an experimental approach for the identification of arterial occlusion condition. Arterial occlusion occurs due to development of constriction and/or thrombus in the lumen of the artery. A geometry of the thrombus has been modeled for the analys...
| Publicado en: | Journal of Medical Systems Vol. 46; no. 11; pp. 1 - 17 |
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| Autores principales: | , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Nov2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159925825&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159925825 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01485598 4N0 jtl: Journal of Medical Systems issn: 01485598 maglogo: N pubinfo: dt: Nov2022 vid: 46 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159925825 159925825 159925825 10.1007/s10916-022-01861-9 159925825 ppf: 1 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Modeling, Simulation and Validation of Alteration in Blood Flow and Regional Oxygenation Under Arterial Occlusion. aug: au: Ahirwar, Dalchand Khurana, Dheeraj Chowdhury, Shubhajit Roy affil: Biomedical Systems Laboratory, School of Computing and Electrical Engineering, Indian Institute of Technology, Mandi, India sug: subj: Blood Flow Velocity Evaluation Oxygenation Arterial Occlusive Diseases Oxygen Saturation Human Experimental Studies Spectroscopy, Near-Infrared Descriptive Statistics Confidence Intervals Cerebral Arteries Pathology Radial Artery Pathology Simulations Funding Source T-Tests Ischemic Stroke Risk Factors ab: The paper presents the mathematical modeling along with an experimental approach for the identification of arterial occlusion condition. Arterial occlusion occurs due to development of constriction and/or thrombus in the lumen of the artery. A geometry of the thrombus has been modeled for the analysis of the arterial occlusion condition in modeling part. The proposed model of the thrombus has been simulated using Comsol® multiphysics considering different hemodynamic parameters. Variation in regional oxygen saturation (rSO2) of the arterial occlusion condition has been validated with experimental process, where occlusion of the artery has been done by applying external pressure. The experimental study has been conducted to monitor alteration in rSO2 level profile for occlusion using near infrared spectroscopy (NIRS) methodology. NIRS signal data has been collected from twenty-three subjects with no reported musculoskeletal, psychiatric, or any other neurological deficits using Mespere NeurOs® oxymeter. Experimental data reveal that the oxygenation level decreases considerably due to arterial occlusion as compared to the healthy condition at 95% of confidence interval (p <.05). Dynamic time warping algorithm reveals that variation in rSO2 due to proposed thrombus geometry has more similarity with experimental study. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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