Electrophysiological and behavioral correlates of cannabis use disorder.
Current research indicates deficits in cognitive function together with widespread changes in brain activity following long-term cannabis use. In particular, cannabis use has been associated with excessive spectral power of the alpha rhythm (8–12 Hz), which is also known to be modulated during atten...
| Publicado en: | Cognitive, Affective & Behavioral Neuroscience Vol. 22; no. 6; pp. 1421 - 1432 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159974037&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159974037 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Dec2022 vid: 22 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159974037 157409062 10.3758/s13415-022-01016-w 159974037 ppf: 1421 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Electrophysiological and behavioral correlates of cannabis use disorder. aug: au: Andriot, Théo Ohnmacht, Patrick Vuilleumier, Patrik Thorens, Gabriel Khazaal, Yasser Ginovart, Nathalie Ros, Tomas affil: Department of Basic Neurosciences, University of Geneva, Geneva, Switzerland sug: ab: Current research indicates deficits in cognitive function together with widespread changes in brain activity following long-term cannabis use. In particular, cannabis use has been associated with excessive spectral power of the alpha rhythm (8–12 Hz), which is also known to be modulated during attentional states. Recent neuroimaging studies have linked heavy cannabis use with structural and metabolic changes in the brain; however, the functional consequences of these changes are still not fully characterized. This study investigated the electrophysiological and behavioral correlates of cannabis dependence by comparing patients with a cannabis use disorder (CUD; N = 24) with cannabis nonuser controls (N = 24), using resting state electroencephalogram (EEG) source-imaging. In addition to evaluating mean differences between groups, we also explored whether particular EEG patterns were associated with individual cognitive-behavioral measures. First, we replicated historical findings of elevated levels of (relative) alpha rhythm in CUD patients compared with controls and located these abnormalities to mainly prefrontal cortical regions. Importantly, we observed a significant negative correlation between alpha spectral power in several cortical regions and individual attentional performance in the Go/NoGo task. Because such relationship was absent in the nonuser control group, our results suggest that reduced prefrontal cortical activation (indexed by increased relative alpha power) could be partly responsible for the reported cognitive impairments in CUD. Our findings support the use of electroencephalography as a noninvasive and cost-effective tool for biomarker discovery in substance abuse and have the potential of directly informing future intervention strategies. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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