Impairments in goal-directed action and reversal learning in a proportion of individuals with psychosis.
Cognitive impairment in psychosis is one of the strongest predictors of functional decline. Problems with decision-making processes, such as goal-directed action and reversal learning, can reflect cortico-striatal dysfunction. The heterogenous symptoms and neurobiology observed in those with psychos...
| Publicado en: | Cognitive, Affective & Behavioral Neuroscience Vol. 22; no. 6; pp. 1390 - 1404 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=159974045&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 159974045 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Dec2022 vid: 22 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 159974045 158289444 10.3758/s13415-022-01026-8 159974045 ppf: 1390 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Impairments in goal-directed action and reversal learning in a proportion of individuals with psychosis. aug: au: Suetani, Shuichi Baker, Andrea Garner, Kelly Cosgrove, Peter Mackay-Sim, Matilda Siskind, Dan Murray, Graham K Scott, James G Kesby, James P. affil: Queensland Centre for Mental Health Research, 4076, Brisbane, QLD, Australia sug: ab: Cognitive impairment in psychosis is one of the strongest predictors of functional decline. Problems with decision-making processes, such as goal-directed action and reversal learning, can reflect cortico-striatal dysfunction. The heterogenous symptoms and neurobiology observed in those with psychosis suggests that specific cognitive phenotypes may reflect differing causative mechanisms. As such, decision-making performance could identify subgroups of individuals with more severe cortico-striatal dysfunction and help to predict their functional decline. The present work evaluated the relationship between goal-directed action, reversal learning, and symptom profiles in those with psychosis. We assessed decision-making processes in healthy controls (N = 34) and those with persistent psychosis (N = 45), subclassifying subjects based on intact/impaired goal-directed action. Compared with healthy controls (<20%), a large proportion (58%) of those with persistent psychosis displayed impaired goal-directed action, predicting poor serial reversal learning performance. Computational approaches indicated that those with impaired goal-directed action had a decreased capacity to rapidly update their prior beliefs in the face of changing contingencies. Impaired decision-making also was associated with reduced levels of grandiosity and increased problems with abstract thinking. These findings suggest that prominent decision-making deficits, indicative of cortico-striatal dysfunction, are present in a large proportion of people with persistent psychosis. Moreover, these impairments would have significant functional implications in terms of planning and abstract thinking. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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