Effect of immunoglobulin Y formulations on oral microorganisms in human subjects - A systematic review and meta-analysis of clinical trials.
Background: Passive immunization using egg yolk-based antibodies has been tested against oral microorganisms. Our study assessed the effect of immunoglobulin Y (IgY) formulations on Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans in human subjects.Highlights: VS and UT independe...
| Published in: | Journal of the Indian Society of Pedodontics & Preventive Dentistry Vol. 40; no. 3; pp. 219 - 230 |
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| Main Authors: | , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
Wolters Kluwer India Pvt Ltd
Jul-Sep2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160064947&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160064947 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09704388 1BS4 jtl: Journal of the Indian Society of Pedodontics & Preventive Dentistry issn: 09704388 maglogo: N pubinfo: dt: Jul-Sep2022 vid: 40 iid: 3 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 160064947 160064947 NLM36260461 160064947 10.4103/jisppd.jisppd_226_22 NLM36260461 160064947 ppf: 219 ppct: 11 formats: tig: atl: Effect of immunoglobulin Y formulations on oral microorganisms in human subjects - A systematic review and meta-analysis of clinical trials. aug: au: Jawdekar, Ashwin Srivastava, Vatsala Tank, Urvashi Mistry, Laresh Jawdekar, Ashwin M Mistry, Laresh Naresh affil: Department of Pediatric and Preventive Dentistry, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Navi Mumbai, Maharashtra sug: subj: Immunoglobulins Pharmacodynamics Immunoglobulins Therapeutic Use Gram-Negative Anaerobic Bacteria Research Subjects Streptococcus Mutans Human Clinical Trials Comparative Studies Meta Analysis Multicenter Studies Evaluation Research Validation Studies Scales Ferrans and Powers Quality of Life Index Systematic Review ab: Background: Passive immunization using egg yolk-based antibodies has been tested against oral microorganisms. Our study assessed the effect of immunoglobulin Y (IgY) formulations on Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans in human subjects.Highlights: VS and UT independently searched articles using keyword combinations in four search engines; studies in English were selected. Either parallel-arm or split-mouth randomized controlled trials on healthy human subjects were considered. Ten studies remained in the selection; six studies compared the effect of IgY formulations on S. mutans, three on P. gingivalis, and one on C. albicans. Five studies (422 subjects) compared the effect of IgY formulations on S. mutans. When fixed-effect model (FEM) was applied, the risk ratio (RR) (confidence interval [CI]) was found to be 7.81 (6.00, 10.18). Three studies (167 subjects) compared the effect of IgY formulations on P. gingivalis. When FEM was applied, the RR (CI) was found to be 0.06 (-0.03, 0.15) in relation to reduction in probing depth. When FEM was applied, for percentage reduction in bleeding on probing (BOP), the RR (CI) was 1.99 (1.64, 2.41). Only one study (26 subjects) was available of IgY formulation and C. albicans; hence meta-analysis was not performed.The search was extended using Google Scholar, Semantic Scholar, cross-references and by contacting authors and researchers in the field which further yielded five articles. .Conclusions: IgY formulations were effective in the reduction of S. mutans. They were not effective on P. gingivalis in relation to probing depth but were effective in relation to reduction in BOP. No harms were reported. Evidence is of low quality due to high heterogeneity. The ROB was moderate and publication bias was low. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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