Antisaccade error rates and gap effects in psychosis syndromes from bipolar-schizophrenia network for intermediate phenotypes 2 (B-SNIP2).
Background: Antisaccade tasks can be used to index cognitive control processes, e.g. attention, behavioral inhibition, working memory, and goal maintenance in people with brain disorders. Though diagnoses of schizophrenia (SZ), schizoaffective (SAD), and bipolar I with psychosis (BDP) are typically...
| Publicado en: | Psychological Medicine Vol. 52; no. 13; pp. 2692 - 2702 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Oct2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160151738&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160151738 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Oct2022 vid: 52 iid: 13 pid: 15979 pub: Cambridge University Press artinfo: ui: 160151738 160151738 160151738 10.1017/S003329172000478X 160151738 ppf: 2692 ppct: 10 formats: tig: atl: Antisaccade error rates and gap effects in psychosis syndromes from bipolar-schizophrenia network for intermediate phenotypes 2 (B-SNIP2). aug: au: Huang, Ling-Yu Jackson, Brooke S. Rodrigue, Amanda L. Tamminga, Carol A. Gershon, Elliot S. Pearlson, Godfrey D. Keshavan, Matcheri S. Keedy, Sarah S. Hill, S. Kristian Sweeney, John A. Clementz, Brett A. McDowell, Jennifer E. affil: Departments of Psychology & Neuroscience, University of Georgia, Athens, GA, USA sug: subj: Saccades Eye Movements Executive Function Task Performance and Analysis Psychotic Disorders Bipolar Disorder Schizophrenia Phenotype Human Cognition Descriptive Statistics Data Analysis Software Post Hoc Analysis Analysis of Variance Male Female Adult Middle Age Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: Antisaccade tasks can be used to index cognitive control processes, e.g. attention, behavioral inhibition, working memory, and goal maintenance in people with brain disorders. Though diagnoses of schizophrenia (SZ), schizoaffective (SAD), and bipolar I with psychosis (BDP) are typically considered to be distinct entities, previous work shows patterns of cognitive deficits differing in degree, rather than in kind, across these syndromes. Methods: Large samples of individuals with psychotic disorders were recruited through the Bipolar-Schizophrenia Network on Intermediate Phenotypes 2 (B-SNIP2) study. Anti- and pro-saccade task performances were evaluated in 189 people with SZ, 185 people with SAD, 96 people with BDP, and 279 healthy comparison participants. Logistic functions were fitted to each group's antisaccade speed-performance tradeoff patterns. Results: Psychosis groups had higher antisaccade error rates than the healthy group, with SZ and SAD participants committing 2 times as many errors, and BDP participants committing 1.5 times as many errors. Latencies on correctly performed antisaccade trials in SZ and SAD were longer than in healthy participants, although error trial latencies were preserved. Parameters of speed-performance tradeoff functions indicated that compared to the healthy group, SZ and SAD groups had optimal performance characterized by more errors, as well as less benefit from prolonged response latencies. Prosaccade metrics did not differ between groups. Conclusions: With basic prosaccade mechanisms intact, the higher speed-performance tradeoff cost for antisaccade performance in psychosis cases indicates a deficit that is specific to the higher-order cognitive aspects of saccade generation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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