Potential inflammatory biomarkers for tinnitus in platelets and leukocytes: a critical scoping review and meta-analysis.
To explore the association between platelets or leukocytes and tinnitus. A meta-analysis and scoping review examining the association between tinnitus and platelets and leukocytes. All 11 studies included were critically appraised using the Joanna Briggs Institute (JBI) checklist (2017a). A random e...
| Publicado en: | International Journal of Audiology Vol. 61; no. 11; pp. 905 - 917 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160164980&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160164980 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14992027 JW2 jtl: International Journal of Audiology issn: 14992027 maglogo: Y pubinfo: dt: Nov2022 vid: 61 iid: 11 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 160164980 160164980 160164980 10.1080/14992027.2021.2018511 160164980 ppf: 905 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Potential inflammatory biomarkers for tinnitus in platelets and leukocytes: a critical scoping review and meta-analysis. aug: au: Ahmed, Raheel Shadis, Alice Ahmed, Rumana affil: College of Human and Health Sciences, Swansea University, Swansea, UK sug: subj: Tinnitus Diagnosis Inflammation Biological Markers Blood Blood Platelets Leukocytes Human Scoping Review Meta Analysis Mean Platelet Volume Checklists Descriptive Statistics Comparative Studies Confidence Intervals Neutrophil Lymphocyte Ratio Platelet Lymphocyte Ratio Medline PubMed CINAHL Database Data Analysis Software ab: To explore the association between platelets or leukocytes and tinnitus. A meta-analysis and scoping review examining the association between tinnitus and platelets and leukocytes. All 11 studies included were critically appraised using the Joanna Briggs Institute (JBI) checklist (2017a). A random effects model was used to pool the results of the studies examining mean platelet volume (MPV) and tinnitus. 1935 studies were identified in the initial search, 11 of which were included in the scoping review. 6 of the 11 studies had their MPV values pooled in the meta-analysis. Pooled results of 818 subjects from 6 studies indicated that MPV was significantly higher in those with tinnitus compared to a comparison group without tinnitus. The overall mean difference was 0.43 fL with a 95% confidence interval (CI) from 0.31 to 0.55 and a p value of < 0.0001 which was statistically significant. MPV is the only haematological parameter which is reliably associated with tinnitus. MPV could be a useful biomarker for tinnitus. Further studies should aim to standardise methodology with more rigorous exclusion criteria to reproduce and define this association. NLR, PLR, WBC count, RDW and PDW do not show a reliable association with tinnitus. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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