National record-linkage study of hospital admissions for schizophrenia in childhood and adolescence in England.

Background: There is a lack of information on changes in hospital admission rates for childhood-onset schizophrenia (COS), or on patient characteristics, to inform clinical research and health service provision. Aims: To report age- and sex-specific incidence rates of hospital admissions and day pat...

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Publicado en:European Child & Adolescent Psychiatry Vol. 31; no. 12; pp. 1943 - 1952
Autores principales: Seminog, Olena, Hoang, Uy, Goldacre, Michael, James, Anthony
Formato: research tables/charts Journal Article
Publicado: Springer Nature Dec2022
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2022
      vid: 31
      iid: 12
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00787-021-01817-3
        160202012
      ppf: 1943
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        atl: National record-linkage study of hospital admissions for schizophrenia in childhood and adolescence in England.
      aug:
        au:
          Seminog, Olena
          Hoang, Uy
          Goldacre, Michael
          James, Anthony
        affil: Unit of Health-Care Epidemiology, Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Old Road Campus, OX3 7LF, Oxford, UK
      sug:
        subj:
          Patient Admission
          Hospitalization
          Schizophrenia Epidemiology
          Day Care
          Age Factors
          Schizophrenia In Infancy and Childhood
          Schizophrenia In Adolescence
          England
          Human
          Confidence Intervals
          Male
          Female
          Age of Onset
          Electronic Health Records
          Child
          Adolescence
          Child: 6-12 years
          Adolescent: 13-18 years
          Male
          Female
      ab: Background: There is a lack of information on changes in hospital admission rates for childhood-onset schizophrenia (COS), or on patient characteristics, to inform clinical research and health service provision. Aims: To report age- and sex-specific incidence rates of hospital admissions and day patient care for schizophrenia (ICD-10 F20) and non-affective psychosis (ICD-10 F20-29), by year of occurrence and age, in childhood and adolescence. Methods: Population-based study using person-linked data for England (available 2001–2016); time-periods in single years and 4-year groups. Results: Hospitalised incidence for schizophrenia increased with increasing age, from 0.03 (95% confidence interval (CI) 0.02–0.05) and 0.01 (0–0.01) per 100,000 in, respectively, males and females aged 5–12 years, to 3.67 (3.44–3.91) in males and 1.58 (1.43–1.75) in females aged 13–17 years. There was no gender difference in hospitalised incidence rates in children aged 5–12, but in 13–17 years old, there was a male excess. Rates for schizophrenia were stable over time in 5–12 years old. In ages 13–17, rates for schizophrenia decreased between 2001–2004 and 2013–2016 in males, from 6.65 (6.04–7.31) down to 1.40 (1.13–1.73), and in females from 2.42 (2.05–2.83) to 1.18 (0.92–1.48). The hospitalisation rates for schizophrenia and non-affective psychosis, combined, in 13–17 years old decreased in males from 14.20 (13.30–15.14) in 2001–2004 to 10.77 (9.97–11.60) in 2013–2016, but increased in females from 7.49 (6.83–8.20) to 10.16 (9.38–11.00). Conclusions: The study confirms that childhood-onset schizophrenia is extremely rare, with only 32 cases identified over a 15-year period in the whole of England. The incidence of schizophrenia and non-affective psychosis increased substantially in adolescence; however, the marked reduction in the proportion of those diagnosed with schizophrenia in this age group suggests a possible change in diagnostic practice.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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