Apigenin attenuates LPS-induced neurotoxicity and cognitive impairment in mice via promoting mitochondrial fusion/mitophagy: role of SIRT3/PINK1/Parkin pathway.

Rationale: Alteration of the NAD+ metabolic pathway is proposed to be implicated in lipopolysaccharide (LPS)-induced neurotoxicity and mitochondrial dysfunction in neurodegenerative diseases. Apigenin, a naturally-occurring flavonoid, has been reported to maintain NAD+ levels and to preserve various...

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Bibliographic Details

Published in:	Psychopharmacology Vol. 239; no. 12; pp. 3903 - 3918
Main Authors:	Ahmedy, Omaima A., Abdelghany, Tarek M., El-Shamarka, Marwa E. A., Khattab, Mohamed A., El-Tanbouly, Dalia M.
Format:	Journal Article
Published:	Springer Nature Dec2022
Online Access:	View this record in EBSCOhost