Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression.
The somatic depressive symptom cluster (including appetite and sleep disturbances) is more strongly associated with insulin resistance (a diabetes risk marker) than other depressive symptom clusters. Utilizing baseline data from 129 primary care patients with depression but no diabetes in the eIMPAC...
| Publicado en: | Journal of Behavioral Medicine Vol. 45; no. 6; pp. 882 - 894 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160294849&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160294849 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01607715 JBM jtl: Journal of Behavioral Medicine issn: 01607715 maglogo: N pubinfo: dt: Dec2022 vid: 45 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 160294849 159015397 160294849 160294849 10.1007/s10865-022-00356-9 160294849 ppf: 882 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Associations of somatic depressive symptoms with body mass index, systemic inflammation, and insulin resistance in primary care patients with depression. aug: au: Shell, Aubrey L. Williams, Michelle K. Patel, Jay S. Vrany, Elizabeth A. Considine, Robert V. Acton, Anthony J. Stewart, Jesse C. affil: Department of Psychology, Indiana University-Purdue University Indianapolis (IUPUI), 402 North Blackford Street, LD 100E, IN 46202, Indianapolis, United States sug: subj: Somatoform Disorders Depression Body Mass Index Systemic Inflammatory Response Syndrome Insulin Resistance Primary Health Care Hyperphagia C-Reactive Protein Disorders of Excessive Somnolence White Persons African Americans Data Analysis Software Descriptive Statistics Human Male Female Middle Age Aged Middle Aged: 45-64 years Aged: 65+ years Male Female ab: The somatic depressive symptom cluster (including appetite and sleep disturbances) is more strongly associated with insulin resistance (a diabetes risk marker) than other depressive symptom clusters. Utilizing baseline data from 129 primary care patients with depression but no diabetes in the eIMPACT trial (Mage = 59 years, 78% female, 50% Black), we examined associations of somatic depressive symptoms with insulin resistance (HOMA-IR), body mass index (BMI), and high-sensitivity C-reactive protein (hsCRP). We tested BMI and hsCRP as mediators and race as a moderator of these relationships. Hyperphagia was positively associated HOMA-IR (β = 0.19, p =.048) and BMI (β = 0.30, p <.001); poor appetite was negatively associated with HOMA-IR (β = -0.24, p =.02); hypersomnia was positively associated with HOMA-IR (β = 0.28, p =.003), BMI (β = 0.26, p =.003), and hsCRP (β = 0.23, p =.01); and disturbed sleep was positively associated with hsCRP (β = 0.21, p =.04). BMI partially mediated hyperphagia and hypersomnia's associations with HOMA-IR; hsCRP partially mediated the hypersomnia-HOMA-IR association; and race moderated the hyperphagia-HOMA-IR association (positive for White participants but null for Black participants). People with depression experiencing hyperphagia and/or hypersomnia may be a subgroup with greater insulin resistance; BMI and hsCRP are likely pathways in these relationships. This study highlights the importance of considering the direction of somatic depressive symptoms in the context of cardiometabolic disease risk. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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