Changes in women's physical function in mid-life by reproductive age and hormones: a longitudinal study.
Background: Whether women's physical function in mid-life is related to their reproductive age is not known. The objectives of this study were to examine and compare changes in physical function in women by reproductive age, measured as time since final menstrual period (FMP), and chronological age,...
| Publicado en: | BMC Women's Health Vol. 22; no. 1; pp. 1 - 11 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
11/24/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160424079&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160424079 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14726874 1CIP jtl: BMC Women's Health issn: 14726874 maglogo: N pubinfo: dt: 11/24/2022 vid: 22 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 160424079 160424079 NLM36434722 160424079 10.1186/s12905-022-02070-9 NLM36434722 160424079 ppf: 1 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Changes in women's physical function in mid-life by reproductive age and hormones: a longitudinal study. aug: au: Kilpi, Fanny Soares, Ana Goncalves Clayton, Gemma L. Fraser, Abigail Welsh, Paul Sattar, Naveed Nelson, Scott M. Tilling, Kate Lawlor, Deborah A. affil: MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, BS8 2BN, Bristol, UK sug: subj: Aging Menopause Prospective Studies Follicle-Stimulating Hormone Child Reproduction Female Funding Source Human Child: 6-12 years Female ab: Background: Whether women's physical function in mid-life is related to their reproductive age is not known. The objectives of this study were to examine and compare changes in physical function in women by reproductive age, measured as time since final menstrual period (FMP), and chronological age, and to explore associations with repeatedly assessed levels of reproductive hormones.Methods: We used data from 2319 UK women with up to three repeated measurements of physical function (median length of follow up: 2 years), focusing on changes occurring in women experiencing a natural menopausal transition. The main outcome was a composite physical function score that incorporated assessments of strength (grip strength), balance (one-leg stand) and cardiorespiratory fitness (timed chair rises). Associations with time since FMP, age, and time-updated measures of anti-Müllerian hormone, follicle-stimulating hormone and luteinizing hormone were assessed by multilevel models and generalised estimating equations models adjusted for the underlying effects of chronological age and confounding by education, age at first birth and smoking.Results: The results showed that, adjusted for these confounders, time since FMP (- 0.21 SD per 10 years, 95% CI - 0.37, - 0.06) and chronological age (- 0.31 SD per 10 years, 95% CI - 0.46, - 0.15) were inversely associated with the physical function composite score. Grip strength seemed to be the main contributor to the decline in the composite score by time since FMP. There was no strong evidence of associations between any of the three reproductive hormones and the composite score.Conclusions: Physical function in women in mid-life declined with both chronological and reproductive age. The decline with reproductive age was independent of chronological age but did not seem to be driven by changes in reproductive hormones. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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