Automated segmentation of whole-body CT images for body composition analysis in pediatric patients using a deep neural network.
Objectives: To develop an automatic segmentation algorithm using a deep neural network with transfer learning applicable to whole-body PET-CT images in children.Methods: For model development, we utilized transfer learning with a pre-trained model based on adult patients. We used CT images of 31 ped...
| Published in: | European Radiology Vol. 32; no. 12; pp. 8463 - 8473 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Dec2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160459176&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160459176 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2022 vid: 32 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 160459176 156703694 160459176 NLM35524785 10.1007/s00330-022-08829-w NLM35524785 160459176 ppf: 8463 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Automated segmentation of whole-body CT images for body composition analysis in pediatric patients using a deep neural network. aug: au: Lee, Seul Bi Cho, Yeon Jin Yoon, Soon Ho Lee, Yun Young Kim, Soo-Hyun Lee, Seunghyun Choi, Young Hun Cheon, Jung-Eun affil: Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 03080, Seoul, Republic of Korea sug: subj: Child Adult Body Composition Tomography, X-Ray Computed Methods Child: 6-12 years Adult: 19-44 years ab: Objectives: To develop an automatic segmentation algorithm using a deep neural network with transfer learning applicable to whole-body PET-CT images in children.Methods: For model development, we utilized transfer learning with a pre-trained model based on adult patients. We used CT images of 31 pediatric patients under 19 years of age (mean age, 9.6 years) who underwent PET-CT from institution #1 for transfer learning. Two radiologists manually labeled the skin, bone, muscle, abdominal visceral fat, subcutaneous fat, internal organs, and central nervous system in each CT slice and used these as references. For external validation, we collected 14 pediatric PET/CT scans from institution #2 (mean age, 9.1 years). The Dice similarity coefficients (DSCs), sensitivities, and precision were compared between the algorithms before and after transfer learning. In addition, we evaluated segmentation performance according to sex, age (≤ 8 vs. > 8 years), and body mass index (BMI, ≤ 20 vs. > 20 kg/m2).Results: The algorithm after transfer learning showed better performance than the algorithm before transfer learning for all body compositions (p < 0.001). The average DSC, sensitivity, and precision of each algorithm before and after transfer learning were 98.23% and 99.28%, 98.16% and 99.28%, and 98.29% and 99.28%, respectively. The segmentation performance of the algorithm was generally not affected by age, sex, or BMI, except for precision in the body muscle compartment.Conclusion: The developed model with transfer learning enabled accurate and fully automated segmentation of multiple tissues on whole-body CT scans in children.Key Points: • We utilized transfer learning with a pre-trained segmentation algorithm for adult to develop an algorithm for automated segmentation of pediatric whole-body CT. • This algorithm showed excellent performance and was not affected by sex, age, or body mass index, except for precision in body muscle. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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