Humoral immunity in dually vaccinated SARS-CoV-2-naïve individuals and in booster-vaccinated COVID-19-convalescent subjects.
Background: The immune response to COVID-19-vaccination differs between naïve vaccinees and those who were previously infected with SARS-CoV-2. Longitudinal quantitative and qualitative serological differences in these two distinct immunological subgroups in response to vaccination are currently not...
| Publicado en: | Infection Vol. 50; no. 6; pp. 1475 - 1482 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160459259&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160459259 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Dec2022 vid: 50 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 160459259 156250072 160459259 160459259 10.1007/s15010-022-01817-8 160459259 ppf: 1475 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Humoral immunity in dually vaccinated SARS-CoV-2-naïve individuals and in booster-vaccinated COVID-19-convalescent subjects. aug: au: Glück, Vivian Tydykov, Leonid Mader, Anna-Lena Warda, Anne-Sophie Bertok, Manuela Weidlich, Tanja Gottwald, Christine Köstler, Josef Salzberger, Bernd Wagner, Ralf Koller, Michael Gessner, André Schmidt, Barbara Glück, Thomas Peterhoff, David affil: Institute for Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany sug: subj: COVID-19 Vaccines COVID-19 Drug Therapy Immunity Antibody Formation Immunization, Secondary Human Immunization Quantitative Studies Qualitative Studies Enzyme-Linked Immunosorbent Assay Neutralization Tests Immunoglobulins Antigen-Antibody Reactions ab: Background: The immune response to COVID-19-vaccination differs between naïve vaccinees and those who were previously infected with SARS-CoV-2. Longitudinal quantitative and qualitative serological differences in these two distinct immunological subgroups in response to vaccination are currently not well studied. Methods: We investigate a cohort of SARS-CoV-2-naïve and COVID-19-convalescent individuals immediately after vaccination and 6 months later. We use different enzyme-linked immunosorbent assay (ELISA) variants and a surrogate virus neutralization test (sVNT) to measure IgG serum titers, IgA serum reactivity, IgG serum avidity and neutralization capacity by ACE2 receptor competition. Results: Anti-receptor-binding domain (RBD) antibody titers decline over time in dually vaccinated COVID-19 naïves whereas titers in single dose vaccinated COVID-19 convalescents are higher and more durable. Similarly, antibody avidity is considerably higher among boosted COVID-19 convalescent subjects as compared to dually vaccinated COVID-19-naïve subjects. Furthermore, sera from boosted convalescents inhibited the binding of spike-protein to ACE2 more efficiently than sera from dually vaccinated COVID-19-naïve subjects. Conclusions: Long-term humoral immunity differs substantially between dually vaccinated SARS-CoV-2-naïve and COVID-19-convalescent individuals. Booster vaccination after COVID-19 induces a more durable humoral immune response in terms of magnitude and quality as compared to two-dose vaccination in a SARS-CoV-2-naïve background. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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