Late-long-term potentiation magnitude, but not Ab levels and amyloid pathology, is associated with behavioral performance in a rat knock-in model of Alzheimer disease.
Cleavage of Amyloid precursor protein by β- and γ-secretases lead to Ab formation. The widely accepted pathogenic model states that these mutations cause AD via an increase in Ab formation and accumulation of Ab in Amyloid plaques. APP mutations cause early onset familial forms of Alzheimer's diseas...
| Publicado en: | Frontiers in Aging Neuroscience Vol. 14; pp. 1 - 21 |
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| Autores principales: | , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Frontiers Media S.A.
11/11/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |