Grey matter volume and its association with cognitive impairment and peripheral cytokines in excited individuals with schizophrenia.
Although excited behavior in patients with schizophrenia has been linked to brain structural abnormalities, whether cortical abnormalities in this subgroup are related to cognitive impairment or peripheral immune responses is unknown. We included 28 patients with excitability (EC), 28 patients witho...
| Publicado en: | Brain Imaging & Behavior Vol. 16; no. 6; pp. 2618 - 2627 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160502997&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160502997 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2022 vid: 16 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 160502997 160081677 160502997 NLM36342634 10.1007/s11682-022-00717-7 NLM36342634 160502997 ppf: 2618 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Grey matter volume and its association with cognitive impairment and peripheral cytokines in excited individuals with schizophrenia. aug: au: Fan, Yajuan Gao, Yuan Ma, Qingyan Zhao, Binbin He, Xiaoyan Zhu, Feng Wang, Wei Ma, Xiancang Li, Yening affil: Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, 710061, Xi'an, China sug: subj: Schizophrenia Drug Therapy Schizophrenia Brain Cytokines Gray Matter Magnetic Resonance Imaging Methods Clinical Assessment Tools ab: Although excited behavior in patients with schizophrenia has been linked to brain structural abnormalities, whether cortical abnormalities in this subgroup are related to cognitive impairment or peripheral immune responses is unknown. We included 28 patients with excitability (EC), 28 patients without excitability (NEC), and 48 healthy controls (HCs) to evaluate the associations. Compared with the HC group, the EC and NEC groups showed significant cognitive impairment and increased serum cytokine levels. Analysis of variance in whole-brain grey matter volume (GMV) showed that the volumes of several brain areas, including the superior frontal gyrus (SFG), superior temporal gyrus, and cingulate gyrus, were decreased in patients with schizophrenia. Notably, the left SFG volume was significantly lower in the EC group than in the NEC group. Spearman correlation analysis showed that elevated cytokines were negatively correlated with the GMV of the bilateral SFG, bilateral inferior parietal gyrus, left anterior cingulate gyrus, right fusiform gyrus and parahippocampal gyrus, which were mainly positive correlated with cognitive tests. Moreover, interleukin 4 may contribute to poor scores on Brief Assessment of Cognition and Neuropsychological Assessment Battery by reducing the left SFG volume (17%, Pmediation = 0.044; and 24%, Pmediation = 0.040, respectively). In conclusion, our results confirm GMV changes in excited patients with schizophrenia, and characterize the GMV as an important interface between inflammatory cytokines and cognitive impairment. Therefore, targeted anti-inflammatory adjuvant antipsychotic therapy may improve cognitive function and volumetric brain abnormalities in these patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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