Structural and functional alterations within the Papez circuit in subacute stroke patients.
Beyond causing local injury, stroke disrupts structural and functional organization of the brain networks, exposing patients to a high risk of cognitive impairment by affecting the neural network activity. However, the impact of these pathological changes on cognition-related neural circuits is not...
| Publicado en: | Brain Imaging & Behavior Vol. 16; no. 6; pp. 2681 - 2690 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160503005&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160503005 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Dec2022 vid: 16 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 160503005 159624878 160503005 NLM36222964 10.1007/s11682-022-00727-5 NLM36222964 160503005 ppf: 2681 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Structural and functional alterations within the Papez circuit in subacute stroke patients. aug: au: Yan, Su Li, Yuanhao Lu, Jun Tian, Tian Zhang, Guiling Zhou, Yiran Wu, Di Zhang, Shun Zhu, Wenzhen affil: Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095, Jiefang Avenue, 430030, Wuhan, China sug: subj: Magnetic Resonance Imaging Stroke Hippocampus Cerebral Cortex Limbic System Clinical Assessment Tools Impact of Events Scale ab: Beyond causing local injury, stroke disrupts structural and functional organization of the brain networks, exposing patients to a high risk of cognitive impairment by affecting the neural network activity. However, the impact of these pathological changes on cognition-related neural circuits is not well understood. In this study, we mainly focused on structures and directed functional connectivity within the Papez circuit in subacute stroke patients. Forty-five stroke patients and thirty-four age-, sex-matched healthy controls were included in our study. The Papez circuit gray matter were measured to explore ischemia-induced structural alterations. And Granger causality analysis with the hippocampus as seed regions was performed to identify alterations of directional functional connectivity within the neural circuit. We also explored the associations between cerebral changes with cognitive status. Compared with healthy controls, stroke patients revealed marked atrophy in gray matter of the Papez circuit, including ipsilateral hippocampus, amygdala, thalamus, and caudal anterior cingulate gyrus. Additionally, there are alterations in the directed functional connections between the bilateral hippocampus and cingulate gyrus within the Papez circuit. These altered effective connectivities were correlated with cognitive function after cerebrovascular event. Taken together, in the early post-stroke period, disruptions of the Papez circuit in both architecture and directed functional connectivity have already occurred and might affect the cognitive function. These findings have prompted researchers to better understand the potential mechanisms underlying vascular cognitive impairment and to investigate new therapeutic targets that could reduce cognitive burden. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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