MALDI--TOF--MS for Rapid Screening and Typing of β-Globin Variant and β-Thalassemia through Direct Measurements of Intact Globin Chains.

BACKGROUND: Traditional phenotype-based screening for β-globin variant and β-thalassemia using hematological parameters is time-consuming with low-resolution detection. Development of a MALDI--TOF--MS assay using alternative markers is needed. METHODS: We constructed a MALDI--TOF--MS- based approach...

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Bibliographic Details

Published in:	Clinical Chemistry Vol. 68; no. 12; pp. 1541 - 1552
Main Authors:	Qianqian Zhang, Ge Wang, Dehui Sun, Wanying Lin, Tizhen Yan, Yuanjun Wu, Meiying Wu, Jianhong Chen, Shaomin Zou, Wenchun Xie, Yuqiu Zhou, Yuxi Wang, Linlin He, Yanhui Liu, Zhenxiong Qiu, Lingling Hu, Bin Lin, Xiaoguang Zhou, Yan Li, Xiangmin Xu
Format:	Journal Article
Published:	Oxford University Press / USA Dec2022
Online Access:	View this record in EBSCOhost