SARS-CoV-2 Infection, Hospitalization, and Death in Vaccinated and Infected Individuals by Age Groups in Indiana, 2021‒2022.
Objectives. To assess the effectiveness of vaccine-induced immunity against new infections, all-cause emergency department (ED) and hospital visits, and mortality in Indiana. Methods. Combining statewide testing and immunization data with patient medical records, we matched individuals who received...
| Publicado en: | American Journal of Public Health Vol. 113; no. 1; pp. 96 - 105 |
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| Autores principales: | , , , , , , |
| Formato: | Artículo |
| Publicado: |
American Public Health Association
Jan2023
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=160782931&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 160782931 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00900036 APH jtl: American Journal of Public Health issn: 00900036 maglogo: N pubinfo: dt: Jan2023 vid: 113 iid: 1 pid: 44 pub: American Public Health Association artinfo: ui: 160782931 10.2105/ajph.2022.307112 ppf: 96 ppct: 9 formats: tig: atl: SARS-CoV-2 Infection, Hospitalization, and Death in Vaccinated and Infected Individuals by Age Groups in Indiana, 2021‒2022. aug: au: Tu, Wanzhu Zhang, Pengyue Roberts, Anna Allen, Katie S. Williams, Jennifer Embi, Peter Grannis, Shaun su: Indiana Causes of death Immunization Hospital care Age groups Disease risk factors COVID-19 Hospital emergency services Confidence intervals COVID-19 vaccines Reinfection Disease incidence Vaccine effectiveness Risk assessment Survival analysis (Biometry) Longitudinal method Algorithms Evaluation sug: subj: Causes of death Immunization Hospital care Age groups Disease risk factors Indiana COVID-19 Hospital emergency services Confidence intervals COVID-19 vaccines Reinfection Disease incidence Vaccine effectiveness Risk assessment Survival analysis (Biometry) Longitudinal method Algorithms Evaluation ab: Objectives. To assess the effectiveness of vaccine-induced immunity against new infections, all-cause emergency department (ED) and hospital visits, and mortality in Indiana. Methods. Combining statewide testing and immunization data with patient medical records, we matched individuals who received at least 1 dose of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with individuals with previous SARS-CoV-2 infection on index date, age, gender, race/ethnicity, zip code, and clinical diagnoses. We compared the cumulative incidence of infection, all-cause ED visits, hospitalizations, and mortality. Results. We matched 267 847 pairs of individuals. Six months after the index date, the incidence of SARS-CoV-2 infection was significantly higher in vaccine recipients (6.7%) than the previously infected (2.9%). All-cause mortality in the vaccinated, however, was 37% lower than that of the previously infected. The rates of all-cause ED visits and hospitalizations were 24% and 37% lower in the vaccinated than in the previously infected. Conclusions. The significantly lower rates of all-cause ED visits, hospitalizations, and mortality in the vaccinated highlight the real-world benefits of vaccination. The data raise questions about the wisdom of reliance on natural immunity when safe and effective vaccines are available. (Am J Public Health. 2023;113(1):96–104. https://doi.org/10.2105/AJPH.2022.307112) pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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