A comprehensive evaluation of the quality and complexity of prostate IMRT and VMAT plans generated by an automated inverse planning tool.
Introduction: The Pinnacle3 Auto-Planning (AP) package is an automated inverse planning tool employing a multi-sequence optimisation algorithm. The nature of the optimisation aims to improve the overall quality of radiotherapy plans but at the same time may produce higher modulation, increasing plan...
| Publicado en: | Journal of Radiotherapy in Practice Vol. 21; no. 4; pp. 506 - 513 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Cambridge University Press
Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160850124&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160850124 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14603969 8OJ jtl: Journal of Radiotherapy in Practice issn: 14603969 maglogo: N pubinfo: dt: Dec2022 vid: 21 iid: 4 pid: 15979 pub: Cambridge University Press artinfo: ui: 160850124 160850124 160850124 10.1017/S1460396921000327 160850124 ppf: 506 ppct: 7 formats: tig: atl: A comprehensive evaluation of the quality and complexity of prostate IMRT and VMAT plans generated by an automated inverse planning tool. aug: au: Wilkinson, Dean Mackie, Kelly Novy, Dean Beaven, Frances McNamara, Joanne Bailey, Renee Currie, Michael Nasser, Elias affil: Illawarra Cancer Care Centre, Wollongong, Australia sug: subj: Prostatic Neoplasms Radiotherapy Radiotherapy, Conformal Methods Radiotherapy, Computer-Assisted Methods Dosimetry Methods Dosimetry Evaluation Algorithms Evaluation Human Automation Radiation Dosage Evaluation Radiation Injuries Prevention and Control Patient Positioning Bladder Radiation Effects Rectum Radiation Effects ab: Introduction: The Pinnacle3 Auto-Planning (AP) package is an automated inverse planning tool employing a multi-sequence optimisation algorithm. The nature of the optimisation aims to improve the overall quality of radiotherapy plans but at the same time may produce higher modulation, increasing plan complexity and challenging linear accelerator delivery capability. Methods and materials: Thirty patients previously treated with intensity-modulated radiotherapy (IMRT) to the prostate with or without pelvic lymph node irradiation were replanned with locally developed AP techniques for step-and-shoot IMRT (AP-IMRT) and volumetric-modulated arc therapy (AP-VMAT). Each case was also planned with VMAT using conventional inverse planning. The patient cohort was separated into two groups, those with a single primary target volume (PTV) and those with dual PTVs of differing prescription dose levels. Plan complexity was assessed using the modulation complexity score. Results: Plans produced with AP provided equivalent or better dose coverage to target volumes whilst effectively reducing organ at risk (OAR) doses. For IMRT plans, the use of AP resulted in a mean reduction in bladder V50Gy by 4·2 and 4·7 % (p ≤ 0·01) and V40Gy by 4·8 and 11·3 % (p < 0·01) in the single and dual dose level cohorts, respectively. For the rectum, V70Gy, V60Gy and V40Gy were all reduced in the dual dose level AP-VMAT plans by an average of 2·0, 2·7 and 7·3 % (p < 0·01), respectively. A small increase in plan complexity was observed only in dual dose level AP plans. Findings: The automated nature of AP led to high quality treatment plans with improvement in OAR sparing and minimised the variation in achievable dose planning metrics when compared to the conventional inverse planning approach. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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