Effects of pediatric chronic kidney disease and its etiology on tissue sodium concentration: a pilot study.
Background: Sodium-23 magnetic resonance imaging (23Na MRI) allows non-invasive assessment of tissue sodium concentration ([Na+]). Age and chronic kidney disease (CKD) are associated with increased tissue [Na+] in adults, but limited information is available pertaining to children and adolescents. W...
| Publicado en: | Pediatric Nephrology Vol. 38; no. 2; pp. 499 - 508 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160868334&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160868334 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Feb2023 vid: 38 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 160868334 160868334 160868334 10.1007/s00467-022-05600-7 160868334 ppf: 499 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of pediatric chronic kidney disease and its etiology on tissue sodium concentration: a pilot study. aug: au: Salerno, Fabio R. Akbari, Alireza Lemoine, Sandrine Scholl, Timothy J. McIntyre, Christopher W. Filler, Guido affil: Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada sug: subj: Renal Insufficiency, Chronic Etiology Sodium Metabolism Human Pilot Studies Comparative Studies Case Control Studies Pearson's Correlation Coefficient Fanconi Syndrome Renal Tubular Transport, Inborn Errors Proteinuria Child Child: 6-12 years ab: Background: Sodium-23 magnetic resonance imaging (23Na MRI) allows non-invasive assessment of tissue sodium concentration ([Na+]). Age and chronic kidney disease (CKD) are associated with increased tissue [Na+] in adults, but limited information is available pertaining to children and adolescents. We hypothesized that pediatric CKD is associated with altered tissue [Na+] compared to healthy controls. Methods: This was a case–control exploratory study on healthy children and adults and pediatric CKD patients. Study participants underwent an investigational visit, blood/urine biochemistry, and leg 23Na MRI for tissue [Na+] quantification (whole leg, skin, soleus muscle). CKD was stratified by etiology and patients' tissue [Na+] was compared against healthy controls by computing individual Z-scores. An absolute Z-score > 1.96 was deemed to deviate significantly from the mean of healthy controls. Pearson correlation was used to compute the associations between tissue [Na+] and kidney function. Results: A total of 36 pediatric participants (17 healthy, 19 CKD) and 19 healthy adults completed the study. Healthy adults had significantly higher tissue [Na+] compared with pediatric groups; conversely, no significant differences were found between healthy children/adolescents and CKD patients. Four patients with glomerular disease and one kidney transplant recipient due to atypical hemolytic-uremic syndrome had elevated whole-leg [Na+] Z-scores. Reduced whole-leg [Na+] Z-scores were found in two patients with tubular disorders (Fanconi syndrome, proximal–distal renal tubular acidosis). All tissue [Na+] measures were significantly associated with proteinuria and hypoalbuminemia. Conclusions: Depending on etiology, pediatric CKD was associated with either increased (glomerular disease) or reduced (tubular disorders) tissue [Na+] compared with healthy controls. A higher resolution version of the Graphical abstract is available as Supplementary information. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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