Discoidin domain receptor 1 may be involved in biological barrier homeostasis.
What is known and objective: Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase involved in the pathological processes of several diseases, such as keloid formation, renal fibrosis, atherosclerosis, tumours, and inflammatory processes. The biological barrier is the first line of defenc...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 47; no. 12; pp. 2397 - 2408 |
|---|---|
| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Dec2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160899914&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160899914 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Dec2022 vid: 47 iid: 12 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 160899914 157207053 160899914 160899914 10.1111/jcpt.13705 160899914 ppf: 2397 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: C – @attributes: type: P tig: atl: Discoidin domain receptor 1 may be involved in biological barrier homeostasis. aug: au: Li, Xiaoli Chen, Huiling Zhang, Dekui affil: Lanzhou University Second Hospital, Lanzhou University, Lanzhou, China sug: subj: Receptors, Cell Surface Homeostasis Biological Markers Human Systematic Review Descriptive Statistics Data Analysis Software PubMed ab: What is known and objective: Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase involved in the pathological processes of several diseases, such as keloid formation, renal fibrosis, atherosclerosis, tumours, and inflammatory processes. The biological barrier is the first line of defence against pathogens, and its disruption is closely related to diseases. In this review, we attempt to elucidate the relationship between DDR1 and the biological barrier, explore the potential biological value of DDR1, and review the current research status and clinical potential of DDR1‐selective inhibitors. Methods: We conducted an extensive literature search on PubMed to collect studies on the relevance of DDR1 to biological barriers and DDR1‐selective inhibitors. With these studies, we explored the relationship between DDR1 and biological barriers and briefly reviewed representative DDR1‐selective inhibitors that have been reported in recent years. Results and discussion: First, the review of the potential mechanisms by which DDR1 regulates biological barriers, including the epithelial, vascular, glomerular filtration, blood‐labyrinth, and blood–brain barriers. In the body, DDR1 dysfunction and aberrant expression may be involved in the homeostasis of the biological barrier. Secondly, the review of DDR1 inhibitors reported in recent years shows that DDR1‐targeted inhibition is an attractive and promising pharmacological intervention. What is new and conclusions: This review shows that DDR1 is involved in various physiological and pathological processes and in the regulation of biological barrier homeostasis. However, studies on DDR1 and biological barriers are still scarce, and further studies are needed to elucidate their specific mechanisms. The development of targeted inhibitors provides a new direction and idea to study the mechanism of DDR1. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|