The interplay between DNA methylation and cardiac autonomic system functioning: a systematic review.
Epigenetic marks, particularly DNA methylation (DNAm), are emerging as an important biological marker of susceptibility to cardiac autonomic dysfunction. This review summarizes recent discoveries about the association between DNAm and cardiac autonomic activity. A systematic literature search was pe...
| Publicado en: | International Journal of Environmental Health Research Vol. 33; no. 1; pp. 54 - 71 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=160933757&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 160933757 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09603123 57L jtl: International Journal of Environmental Health Research issn: 09603123 maglogo: Y pubinfo: dt: Jan2023 vid: 33 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 160933757 153482423 160933757 160933757 10.1080/09603123.2021.2000590 160933757 ppf: 54 ppct: 17 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The interplay between DNA methylation and cardiac autonomic system functioning: a systematic review. aug: au: Dos Santos Oliveira, Nayara Cristina Serpeloni, Fernanda Gonçalves de Assis, Simone affil: National Institute of Woman, Child, and Adolescence Health Fernandes Figueira, PPGSCM/IFF/FIOCRUZ, Rio de Janeiro, Brazil sug: subj: DNA Methylation Autonomic Nervous System Cardiovascular System Physiology Biological Markers Human Systematic Review Embase Cochrane Library PubMed Psycinfo Environmental Exposure Stress Stress, Psychological Hypotension Genes Epigenomics Heart Rate Variability ab: Epigenetic marks, particularly DNA methylation (DNAm), are emerging as an important biological marker of susceptibility to cardiac autonomic dysfunction. This review summarizes recent discoveries about the association between DNAm and cardiac autonomic activity. A systematic literature search was performed through the Embase, Web of Science, Cochrane Library, Pubmed, PsycINFO, and Pilots databases. Twenty-two studies met inclusion criteria, of which 18 were human studies including a total of 2,686 participants. DNAm differences in multiple genes, such as NR3C1, TLR2, GPR133, EPO, PHGDH, OXTR, and SLC7A11, linked environmental stressors to physiological responses. For instance, exposure to psychosocial stressors increased NR3C1 methylation, which was associated with both decreased blood pressure and increased parasympathetic activity. Additionally, GPR133 played a potential role in cardiac autonomic dysfunction in an occupational setting, affecting the heart rate's deceleration capacity in welders. This review's findings suggest that DNAm is involved in cardiac autonomic regulation under different stress-mediated responses. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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