Relationships Between Transcranial Doppler Velocity, Von Willebrand Factor, Factor VIII, and Hematological Parameters in Children with Sickle Cell Anemia: A Comparative Cross-Sectional Study.
Background and Objectives: Sickle cell anemia (SCA) is associated with recurrent acute inflammatory processes. These inflammatory processes could lead to elevation of Factor VIII and Von Willebrand Factor levels, thereby increasing the risk of stroke in SCA children. This study aims to determine vWF...
| Publicado en: | Plasmatology Vol. 16; pp. 1 - 9 |
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| Autores principales: | , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
10/1/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161002378&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161002378 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 26348535 MXRV jtl: Plasmatology issn: 26348535 maglogo: Y pubinfo: dt: 10/1/2022 vid: 16 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 161002378 161002378 161002378 10.1177/26348535221130289 161002378 ppf: 1 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Relationships Between Transcranial Doppler Velocity, Von Willebrand Factor, Factor VIII, and Hematological Parameters in Children with Sickle Cell Anemia: A Comparative Cross-Sectional Study. aug: au: Enifeni, Eniola Kehinde Ogbenna, Ann Abiola Daramola, Alaba Olanrewaju Adewoyin, Ademola Samson Olatunya, Oladele Simeon Temiye, Edamisan affil: Department of Hematology and Blood Transfusion, 92958Ekiti State University, Ado Ekiti, Nigeria sug: subj: Ultrasonography, Doppler, Transcranial Blood Coagulation Factors Blood Hematologic Diseases Symptoms Anemia, Sickle Cell Stroke Risk Factors Risk Assessment Human Comparative Studies Cross Sectional Studies Infant Child, Preschool Child Adolescence Cerebrovascular Circulation Evaluation Nigeria Tertiary Health Care Genotype Health Screening Platelet Count Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Adolescent: 13-18 years ab: Background and Objectives: Sickle cell anemia (SCA) is associated with recurrent acute inflammatory processes. These inflammatory processes could lead to elevation of Factor VIII and Von Willebrand Factor levels, thereby increasing the risk of stroke in SCA children. This study aims to determine vWF/FVIII levels in children with SCA and their association with abnormal transcranial Doppler (TCD). Subjects and Methods: This study enrolled 75 children, including 24 SCA cases with normal TCD, 27 SCA cases with abnormal TCD, and 24 Hb AA controls, all aged between 2 and 16 years. Transcranial Doppler (TCD) ultrasound was performed to measure the cerebral blood velocity. Venous blood drawn from each participant was used to determine the levels of von Willebrand Factor Antigen (vWF: Ag) and Factor VIII (FVIII) and the complete blood count (CBC). Relationships among the measured parameters were determined using SPSS version 25. Statistical significance was set at P <.05. Results: FVIII and vWF levels were significantly higher among children with SCA compared to the Hb AA controls (P <.001). Although SCA patients with abnormal TCD tended to have higher levels of FVIII and vWF, this result did not attain statistical significance (P >.05). There was a moderate negative correlation between the left middle cerebral artery and FVIII, (r = −0.332; P =.017). Children with SCA showing an abnormal TCD velocity had significantly higher platelet count compared to those with normal TCD (P =.018). Conclusion: Children with SCA have elevated levels of FVIII and vWF, and an abnormal TCD velocity is associated with elevated platelet count. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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