Enzyme Inhibitory Activities of Extracts and Carpachromene from the Stem of Ficus benghalensis.
Ficus benghalensis is one of the potential medicinal plants which is used locally for the treatment of various ailments such as diabetes, antiasthmatic, and wound healing. To provide a scientific background to these folklores, the current study was designed to evaluate the extract and isolated compo...
| Publicado en: | BioMed Research International Vol. 2022; pp. 1 - 7 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
12/20/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161015036&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161015036 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 12/20/2022 vid: 2022 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 161015036 161015036 161015036 10.1155/2022/7053655 161015036 ppf: 1 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Enzyme Inhibitory Activities of Extracts and Carpachromene from the Stem of Ficus benghalensis. aug: au: Rauf, Abdur Ibrahim, Muhammad Muhammad, Naveed Naz, Saima Wadood, Abdul Khan, Bilal Ali, Toseef Saleem, Muhammad Alsahammari, Abdulrahman Alharbi, Metab Suleria, Hafiz Ansar Rasul affil: Department of Chemistry, University of Swabi, Swabi, Anbar, 23430 Khyber Pakhtunkhwa (KP), Pakistan sug: subj: Plant Extracts Pharmacodynamics Enzyme Inhibitors Drug Effects Plants, Medicinal Plant Stems Pharmacodynamics Medicine, Traditional Human Molecular Structure Ethanol Pharmacodynamics Descriptive Statistics Phosphodiesterase Inhibitors ab: Ficus benghalensis is one of the potential medicinal plants which is used locally for the treatment of various ailments such as diabetes, antiasthmatic, and wound healing. To provide a scientific background to these folklores, the current study was designed to evaluate the extract and isolated compound against various enzymes such as ureases, tyrosinase, and phosphodiesterase. The methanolic extract and carpachromene demonstrated a significant urease inhibition effect with maximum percent inhibition of 72.09 and 92.87%, respectively. Regarding the tyrosinase inhibition, the percent antagonist effect of carpachromene and the methanolic extract was 84.80 and 70.98%, respectively. The phosphodiesterase was also significantly antagonized by crude extract and carpachromene with a maximum percent inhibition of 82.98% and 89.54%, respectively. The docking study demonstrated that the carpachromene fits well into the active site of all three enzymes with significant interactions. Carpachromene might possess the potential to inhibit all three enzymes and can effectively treat different diseases associated with the hyperactivity of these enzymes. In conclusion, the crude extract and carpachromene exhibit significant urease, tyrosinase, and phosphodiesterase inhibitory activity which might be used against various diseases. In conclusion, the crude extract and carpachromene exhibit significant urease, tyrosinase, and phosphodiesterase inhibitory activity which might be used against diabetes and bronchoconstriction. Further, the current study provides scientific backup to the folklore (antidiabetic and antiasthmatic) of Ficus benghalensis. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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