Dual-task related frontal cerebral blood flow changes in older adults with mild cognitive impairment: A functional diffuse correlation spectroscopy study.
Introduction: In a worldwide aging population with a high prevalence of motor and cognitive impairment, it is paramount to improve knowledge about underlying mechanisms of motor and cognitive function and their interplay in the aging processes. Methods: We measured prefrontal cerebral blood flow (CB...
| Published in: | Frontiers in Aging Neuroscience Vol. 14; pp. 1 - 17 |
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| Main Authors: | , , , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Frontiers Media S.A.
12/20/2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161108206&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161108206 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16634365 BG2U jtl: Frontiers in Aging Neuroscience issn: 16634365 maglogo: N pubinfo: dt: 12/20/2022 vid: 14 pid: 40038 pub: Frontiers Media S.A. artinfo: ui: 161108206 161108206 161108206 10.3389/fnagi.2022.958656 161108206 ppf: 1 ppct: 16 formats: tig: atl: Dual-task related frontal cerebral blood flow changes in older adults with mild cognitive impairment: A functional diffuse correlation spectroscopy study. aug: au: Udina, Cristina Avtzi, Stella Mota-Foix, Miriam Rosso, Andrea L. Ars, Joan Frisk, Lisa Kobayashi Gregori-Pla, Clara Durduran, Turgut Inzitari, Marco affil: REFiT Barcelona Research Group, Parc Sanitari Pere Virgili and Vall d'Hebron Research Institute (VHIR), Barcelona, Spain sug: subj: Mild Cognitive Impairment In Old Age Spectrum Analysis Task Performance and Analysis Frontal Lobe Blood Supply Cerebrovascular Circulation Physiology Aging Human Cross Sectional Studies Nonexperimental Studies Descriptive Statistics Data Analysis Software Male Female Aged Aged, 80 and Over Convenience Sample Descriptive Research Confidence Intervals Mann-Whitney U Test Bivariate Statistics Aged: 65+ years Aged, 80 & over Male Female ab: Introduction: In a worldwide aging population with a high prevalence of motor and cognitive impairment, it is paramount to improve knowledge about underlying mechanisms of motor and cognitive function and their interplay in the aging processes. Methods: We measured prefrontal cerebral blood flow (CBF) using functional diffuse correlation spectroscopy during motor and dual-task. We aimed to compare CBF changes among 49 older adults with and without mild cognitive impairment (MCI) during a dual-task paradigm (normal walk, 2-forward count walk, 3-backward count walk, obstacle negotiation, and heel tapping). Participants with MCI walked slower during the normal walk and obstacle negotiation compared to participants with normal cognition (NC), while gait speed during counting conditions was not different between the groups, therefore the dual-task cost was higher for participants with NC. We built a linear mixed effects model with CBF measures from the right and left prefrontal cortex. Results: MCI (n = 34) showed a higher increase in CBF from the normal walk to the 2-forward count walk (estimate = 0.34, 95% CI [0.02, 0.66], p = 0.03) compared to participants with NC, related to a right-sided activation. Both groups showed a higher CBF during the 3-backward count walk compared to the normal walk, while only among MCI, CFB was higher during the 2-forward count walk. Discussion: Our findings suggest a differential prefrontal hemodynamic pattern in older adults with MCI compared to their NC counterparts during the dual-task performance, possibly as a response to increasing attentional demand. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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