Association between walking energy utilisation and longitudinal cognitive performance in older adults.
Background Human motor function is optimised for energetic efficiency, however, age-related neurodegenerative changes affects neuromotor control of walking. Energy utilisation has been associated with motor performance, but its association with cognitive performance is unknown. Methods The study pop...
| Published in: | Age & Ageing Vol. 51; no. 12; pp. 1 - 10 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Article |
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Oxford University Press / USA
Dec2022
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=161116501&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 161116501 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Dec2022 vid: 51 iid: 12 pid: 622 pub: Oxford University Press / USA artinfo: ui: 161116501 10.1093/ageing/afac240 ppf: 1 ppct: 9 formats: tig: atl: Association between walking energy utilisation and longitudinal cognitive performance in older adults. aug: au: Kuo, Pei-Lun An, Yang Gross, Alden L Tian, Qu Zipunnikov, Vadim Spira, Adam P Wanigatunga, Amal A Simonsick, Eleanor M Ferrucci, Luigi Resnick, Susan M Schrack, Jennifer A affil: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD , USA Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD , USA Translational Gerontology Branch, National Institute on Aging, National Institutes of Health , Baltimore, MD , USA Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health , Baltimore, MD , USA Johns Hopkins Center on Aging and Health , Baltimore, MD , USA Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD , USA Department of Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine , Baltimore, MD , USA su: Memory Cross-sectional method Physical fitness Energy metabolism Walking speed Confidence intervals Walking Body movement Research funding Cognition in old age Longitudinal method sug: subj: Memory Cross-sectional method Physical fitness Fitness and Recreational Sports Centers Energy metabolism Walking speed Confidence intervals Walking Body movement Research funding Cognition in old age Longitudinal method keyword: cognition energy expenditure fitness physical performance walking efficiency cognition energy expenditure fitness physical performance walking efficiency ab: Background Human motor function is optimised for energetic efficiency, however, age-related neurodegenerative changes affects neuromotor control of walking. Energy utilisation has been associated with motor performance, but its association with cognitive performance is unknown. Methods The study population included 979 Baltimore Longitudinal Study of Aging participants aged |$\ge$| 50 years (52% female, mean age: 70 |$\pm$| 10.2 years) with a median follow-up time of 4.7 years. Energy utilisation for walking was operationalised as a ratio of the energy cost of slow walking to peak walking energy expenditure during standardised tasks ('cost-ratio'). Cognitive functioning was measured using the Trail Making Tests, California Verbal Learning Test, Wechsler Adult Intelligence Scale (WAIS), letter and category fluency and card rotation tests. Linear mixed models adjusted for demographics, education and co-morbidities assessed the association between baseline cost-ratio and cognitive functioning, cross-sectionally and longitudinally. To investigate the relationship among those with less efficient energy utilisation, subgroup analyses were performed. Results In fully adjusted models, a higher cost-ratio was cross-sectionally associated with poorer performance on all cognitive tests except WAIS (P < 0.05 for all). Among those with compromised energy utilisation, the baseline cost-ratio was also associated with a faster decline in memory (long-delay free recall: β = −0.4, 95% confidence interval [CI] = [−0.8, −0.02]; immediate word recall: β = −1.3, 95% CI = [−2.7, 0.1]). Conclusions These findings suggest cross-sectional and longitudinal links between energy utilisation and cognitive performance, highlighting an intriguing link between brain function and the energy needed for ambulation. Future research should examine this association earlier in the life course to gauge the potential for interventive mechanisms. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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