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DropWise: current role and future perspectives of dried blood spots (DBS), blood microsampling, and their analysis in sports drug testing.

For decades, blood testing has been an integral part of routine doping controls. The breadth of information contained in blood samples has become considerably more accessible for anti-doping purposes over the last 10 years through technological advancements regarding analytical instrumentation as we...

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Published in:Critical Reviews in Clinical Laboratory Sciences Vol. 60; no. 1; pp. 41 - 63
Main Authors: Thevis, M., Walpurgis, Katja, Thomas, A.
Format: pictorial review tables/charts Journal Article
Published: Taylor & Francis Ltd Jan2023
Online Access:View this record in EBSCOhost
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      dt: Jan2023
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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        10.1080/10408363.2022.2103085
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        atl: DropWise: current role and future perspectives of dried blood spots (DBS), blood microsampling, and their analysis in sports drug testing.
      aug:
        au:
          Thevis, M.
          Walpurgis, Katja
          Thomas, A.
        affil: Institute of Biochemistry/Center for Preventive Doping Research, German Sport University Cologne, Cologne, Germany
      sug:
        subj:
          Doping in Sports
          Substance Abuse Detection Methods
          Blood Chemical Analysis Methods
          Blood Specimen Collection Methods
          Hormones Blood
          Chemistry, Analytical Methods
          Chemistry, Analytical Equipment and Supplies
          Erythrocytes Analysis
          Mass Spectrometry
          Health Care Costs
      ab: For decades, blood testing has been an integral part of routine doping controls. The breadth of information contained in blood samples has become considerably more accessible for anti-doping purposes over the last 10 years through technological advancements regarding analytical instrumentation as well as enhanced sample collection systems. Particularly, microsampling of whole blood and serum, for instance as dried blood spots (DBS), has opened new avenues in sports drug testing and substantially increased the availability and cost-effectiveness of doping control specimens. Thus, microvolume blood specimens possess the potential to improve monitoring of blood hormone and drug levels, support evaluation of circulating drug concentrations in competition, and enhance the stability of labile markers and target analytes in blood passport analyses as well as peptide hormone and steroid ester detection. Further, the availability of the fraction of lysed erythrocytes for anti-doping purposes warrants additional investigation, considering the sequestering capability of red blood cells (RBCs) for certain substances, as a complementary approach in support of the clean sport.
      pubtype: Academic Journal
      doctype:
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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