Dose-dependent early white matter alterations in patients with brain metastases after radiotherapy.
Purpose: Previous diffusion tensor imaging (DTI) studies have mainly focused on dose-dependent white matter (WM) alterations 1 month to 1 year after radiation therapy (RT) with a tract-average method. However, WM alterations immediately after RT are subtle, resulting in early WM alterations that can...
| Publicado en: | Neuroradiology Vol. 65; no. 1; pp. 167 - 177 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images equations & formulas research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161158816&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161158816 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jan2023 vid: 65 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161158816 158099123 161158816 161158816 10.1007/s00234-022-03020-w 161158816 ppf: 167 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dose-dependent early white matter alterations in patients with brain metastases after radiotherapy. aug: au: Wang, Yixin Liu, Jin Lang, Jinwei Hu, Zongtao Xu, Xiuli Zhang, Yongkang Chen, Qi Yang, Lizhuang Wang, Hongzhi Li, Hai affil: Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230031, Hefei, People's Republic of China sug: subj: Brain Neoplasms Radiotherapy Neoplasm Metastasis Radiotherapy White Matter Radiation Effects Dose-Response Relationship, Radiation Human Magnetic Resonance Imaging Methods Radiation Dosage Left Brain Hemisphere Radiation Effects Dosimetry Funding Source ab: Purpose: Previous diffusion tensor imaging (DTI) studies have mainly focused on dose-dependent white matter (WM) alterations 1 month to 1 year after radiation therapy (RT) with a tract-average method. However, WM alterations immediately after RT are subtle, resulting in early WM alterations that cannot be detected by tract-average methods. Therefore, we performed a study with an along-tract method in patients with brain metastases to explore the early dose–response pattern of WM alterations after RT. Methods: Sixteen patients with brain metastases underwent DTI before and 1–3 days after brain RT. DTI metrics, such as fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD), were calculated. Along-tract statistics were then used to resample WM fibre streamlines and generate a WM skeleton fibre tract. DTI metric alterations (post_RT-pre_RT DTI metrics) and the planned doses (max or mean doses) were mapped to 18 WM tracts. A linear fixed model was performed to analyse the main effect of dose on DTI metric alterations. Results: AD alterations in the left hemispheric uncinated fasciculus (UNC_L) were associated with max doses, in which decreased AD alterations were associated with higher doses. Conclusion: Our findings may provide pathological insight into early dose-dependent WM alterations and may contribute to the development of max dose-constrained RT techniques to protect brain microstructure in the UNC_L. pubtype: Academic Journal doctype: diagnostic images equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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