Brain functional connectivity differences between responders and non-responders to sleeve gastrectomy.
Purpose: To compare resting-state functional connectivity (RSFC) of obese patients responders or non-responders to sleeve gastrectomy (SG) with a group of obese patients with no past medical history of metabolic or bariatric surgery. Methods: MR images were acquired at 1.5 Tesla. Resting-state fMRI...
| Publicado en: | Neuroradiology Vol. 65; no. 1; pp. 131 - 144 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161158824&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161158824 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jan2023 vid: 65 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161158824 158567096 161158824 161158824 10.1007/s00234-022-03043-3 161158824 ppf: 131 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Brain functional connectivity differences between responders and non-responders to sleeve gastrectomy. aug: au: Mallio, Carlo A. Spagnolo, Giuseppe Piervincenzi, Claudia Petsas, Nikolaos Boccetti, Danilo Spani, Federica Gallo, Ida Francesca Sisto, Antonella Quintiliani, Livia Di Gennaro, Gianfranco Bruni, Vincenzo Quattrocchi, Carlo C. affil: Unit of Diagnostic Imaging, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy sug: subj: Brain Physiology Brain Mapping Gastrectomy Methods Obesity Bariatric Surgery Functional Connectivity Magnetic Resonance Imaging Methods Neural Pathways Human Male Female Adult Middle Age Weight Loss Physiology Spearman's Rank Correlation Coefficient Frontal Lobe Parietal Lobe Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: To compare resting-state functional connectivity (RSFC) of obese patients responders or non-responders to sleeve gastrectomy (SG) with a group of obese patients with no past medical history of metabolic or bariatric surgery. Methods: MR images were acquired at 1.5 Tesla. Resting-state fMRI data were analyzed with statistical significance threshold set at p < 0.05, family-wise error (FWE) corrected. Results: Sixty-two subjects were enrolled: 20 controls (age range 25–64; 14 females), 24 responders (excess weight loss > 50%; age range 23–68; 17 females), and 18 non-responders to sleeve gastrectomy (SG) (excess weight loss < 50%; age range 23–67; 13 females). About within-network RSFC, responders showed significantly lower RSFC with respect to both controls and non-responders in the default mode and frontoparietal networks, positively correlating with psychological scores. Non-responders showed significantly higher (p < 0.05, family-wise error (few) corrected) RSFC in regions of the lateral visual network as compared to controls. Regarding between-network RSFC, responders showed significantly higher anti-correlation between executive control and salience networks (p < 0.05, FWE corrected) with respect to both controls and non-responders. Significant positive correlation (Spearman rho = 0.48, p = 0.0012) was found between % of excess weight loss and executive control-salience network RSFC. Conclusion: There are differences in brain functional connectivity in either responders or non-responders patients to SG. The present results offer new insights into the neural correlates of outcome in patients who undergo SG and expand knowledge about neural mechanisms which may be related to surgical response. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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