Does aspirin reduce the incidence, recurrence, and mortality of hepatocellular carcinoma? A GRADE-assessed systematic review and dose–response meta-analysis.
Purpose: Aspirin has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between aspirin use and the risk of occurrence of hepatocellular carcinoma (HCC). The purpose of this study was to assess the effect of aspirin on clinical ou...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 79; no. 1; pp. 39 - 62 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161159751&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161159751 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jan2023 vid: 79 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161159751 160026621 161159751 161159751 10.1007/s00228-022-03414-y 161159751 ppf: 39 ppct: 23 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Does aspirin reduce the incidence, recurrence, and mortality of hepatocellular carcinoma? A GRADE-assessed systematic review and dose–response meta-analysis. aug: au: Ma, Shaodi Qu, Guangbo Sun, Chenyu Liu, Haixia Jiang, Yuemeng Li, Ning Wu, Birong Gao, Juan Feng, Linya Xie, Peng Xia, Weihang Kim, Na Hyun Lowe, Scott Bentley, Rachel Zhu, Yike Zhou, Qin Sun, Yehuan affil: Department of Epidemiology and Health Statistics, School of Public, Health Anhui Medical University, No. 81 Meishan Road, 230032, Hefei, Anhui, People's Republic of China sug: subj: Carcinoma, Hepatocellular Drug Therapy Carcinoma, Hepatocellular Mortality Carcinoma, Hepatocellular Prevention and Control Incidence Recurrence Aspirin Therapeutic Use Treatment Outcomes Dose-Response Relationship Human Systematic Review Meta Analysis Confidence Intervals Descriptive Statistics ab: Purpose: Aspirin has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between aspirin use and the risk of occurrence of hepatocellular carcinoma (HCC). The purpose of this study was to assess the effect of aspirin on clinical outcomes in patients with HCC in a meta-analysis and to explore the possible dose–response relationship. Methods: A systematic literature search was conducted in 10 electronic databases and 4 registries. The combined hazard ratios (HRs) were calculated using a random-effects model with 95% confidence interval (CIs) to assess the effect of aspirin on the risk of HCC. Relevant subgroup analyses and sensitivity analyses were performed. Results: The results show that aspirin use correlated with lower incidence of HCC (HR: 0.75, 95% CI: 0.71–0.80), decreased risk of HCC recurrence (HR: 0.79, 95% CI: 0.65–0.96), and reduced mortality (HR: 0.72, 95% CI: 0.60–0.87). The results of the subgroup analysis showed that aspirin use was consistently associated with reduced incidence of HCC across different regions, study designs, and populations. A linear relationship was found for both dosage and duration of aspirin use. An increased of bleeding with aspirin use among patients was also observed (HR 1.10, 95% CI: 1.02–1.20). Conclusions: This meta-analysis found that aspirin use was independently associated with a reduced risk of HCC incidence, recurrence, and death. Furthermore, aspirin use influenced HCC occurrence in a dose-dependent and duration-dependent manner. However, an increased risk of bleeding with aspirin use was noted. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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