The risk of congenital heart defects associated with corticosteroids use during the first trimester of pregnancy: a systematic review and meta-analysis.
Background: Prior studies have suggested that maternal corticosteroids exposure during the first trimester may be associated with an increased risk of congenital heart defects (CHDs) in offspring. However, the findings are discrepant. Moreover, a complete overview of the existing data in the literat...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 79; no. 1; pp. 1 - 12 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161159753&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161159753 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Jan2023 vid: 79 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161159753 160612956 161159753 161159753 10.1007/s00228-022-03416-w 161159753 ppf: 1 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The risk of congenital heart defects associated with corticosteroids use during the first trimester of pregnancy: a systematic review and meta-analysis. aug: au: Wei, Jiehua Xia, Fan Miao, Junxiang Wang, Tingting Chen, Lizhang Yan, Xuemei affil: Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, 110 Xiangya Road, 410078, Changsha, Hunan, China sug: subj: Heart Defects, Congenital Adrenal Cortex Hormones Adverse Effects Pregnancy Trimester, First Human Female Adult Systematic Review Meta Analysis PubMed Embase Cochrane Library Pregnancy Maternal Exposure Scales Sensitivity and Specificity Prospective Studies Confounding Variable Odds Ratio Confidence Intervals Adult: 19-44 years Female ab: Background: Prior studies have suggested that maternal corticosteroids exposure during the first trimester may be associated with an increased risk of congenital heart defects (CHDs) in offspring. However, the findings are discrepant. Moreover, a complete overview of the existing data in the literature is lacking. Our objective was to identify whether such an association exists. Methods and results: Relevant studies were identified via searching PubMed, Web of Science, Embase, Chinese databases, and the Cochrane Library databases (search date July 15, 2021) and through checking the reference lists of retrieved articles. The overall pooled risk estimate was calculated using random-effect models. We used the GRADE approach to assess the overall strength of the evidence and the Newcastle–Ottawa Scale to assess study quality. Subgroup analyses were performed to evaluate the association within studies or samples with different characteristics. Sensitivity analyses were performed to assess the robustness of the results. Nine studies involving 1,901,599 participants were included in the final analysis. All studies were evaluated as high quality. In the meta-analysis, no statistically significant association was found between maternal corticosteroids exposure during the first trimester and increased risk of CHDs in offspring (OR = 1.06, 95% CI: 1.00–1.13, P = 0.06, low certainty of evidence). Additionally, we also did not find significant differences in subgroup analyses of corticosteroids exposure patterns, including oral corticosteroids exposure (OR = 1.23, 95% CI: 1.00–1.52), ointment corticosteroids exposure (OR = 1.03, 95% CI: 0.90–1.19), inhalation corticosteroids exposure (OR = 1.06, 95% CI: 0.96–1.17), topical corticosteroids or systemic corticosteroids exposure (OR = 0.95, 95% CI: 0.79–1.15), and nasal corticosteroids exposure (OR = 1.12, 95% CI: 0.80–1.57). Conclusions: Our study does not find an association between maternal corticosteroids exposure during the first trimester and offspring CHDs. However, the existing evidence is of low quality; thus, long-term prospective cohort studies are warranted to verify the safety of corticosteroids in this population, with adequate adjustments for confounding variables. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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