Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014.
The aim of this study was to explore urine caffeine metabolites in relation to cognitive performance among 2011-2014 National Health and Nutrition Examination Survey participants aged ≥60 years. We hypothesized that urine caffeine metabolites were positively associated with cognition in older adults...
| Publicado en: | Nutrition Research Vol. 109; pp. 12 - 26 |
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| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jan2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161174116&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161174116 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02715317 KI3 jtl: Nutrition Research issn: 02715317 maglogo: N pubinfo: dt: Jan2023 vid: 109 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 161174116 161174116 161174116 10.1016/j.nutres.2022.11.002 161174116 ppf: 12 ppct: 14 formats: tig: atl: Urine caffeine metabolites are positively associated with cognitive performance in older adults: An analysis of US National Health and Nutrition Examination Survey (NHANES) 2011 to 2014. aug: au: Liu, Di Xie, Fengfei Zeng, Nimei Han, Renfang Cao, Deli Yu, Zengli Wang, Yun Wan, Zhongxiao affil: Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, 199 Ren'ai Road, Suzhou, 215123, China sug: subj: Caffeine Urine Metabolites Cognition Evaluation Cognition Evaluation Human United States Surveys Middle Age Aged Caffeine Metabolism Chromatography, High Pressure Liquid Mass Spectrometry Theophylline Urine Xanthines Urine Odds Ratio Confidence Intervals Multiple Logistic Regression Questionnaires Memory Sex Factors Female Male Middle Aged: 45-64 years Aged: 65+ years Female Male ab: The aim of this study was to explore urine caffeine metabolites in relation to cognitive performance among 2011-2014 National Health and Nutrition Examination Survey participants aged ≥60 years. We hypothesized that urine caffeine metabolites were positively associated with cognition in older adults. Caffeine and 14 of its metabolites were quantified in urine by use of high-performance liquid chromatography-electrospray ionization-tandem quadruple mass spectrometry with stable isotope labeled internal standards. Cognitive assessment was based on scores from the word learning and recall modules. Participants were categorized based on the quartiles of caffeine and its metabolites level. The association between caffeine metabolites and each cognitive dimension was analyzed using multiple logistic regression analysis in adjusted models. Stratification analyses by gender were also performed. For CERAD test, there was a significant association between 1-methyluric acid (OR=0.62, 95% CI: 0.42 to 0.92), 7-methylxanthine(OR=0.49, 95% CI: 0.27 to 0.89), theophylline (OR=0.52, 95% CI: 0.29 to 0.92), as well as paraxanthine (OR=0.49, 95% CI: 0.27 to 0.88) and cognitive function. For animal fluency test, there was a positive association between theophylline (TP) (OR=0.44, 95% CI: 0.22 to 0.89) and cognitive function. The trend that the risk of low cognitive function decreased with increasing concentration of 1-methylxanthine (P trend=0.0229) was also observed. Furthermore, the same trend existed for 3-methylxanthine (p trend = 0.0375) in men. In conclusion, there was a significant positive association between urine caffeine metabolites and cognitive performance in older adults, particularly for theophylline, paraxanthine and caffeine; and the association might be dependent on gender. We aimed to explore the relationship between urine caffeine metabolites and cognitive performance among 2011-2014 NHANES participants aged ≥60 years. There was a significant positive association between theophylline (TP) as well as paraxanthine (PX) and cognitive function. There was a trend towards a negative correlation between low cognitive function and 1-methylxanthine as well as theophylline. The same trend existed for 3-methylxanthine in men by performing stratification analyses. [Display omitted] pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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