Different classes of antibiotics have varying effects on the risk of developing opioid use disorder: a national database study.
To examine whether different classes of antibiotics in combination with opioids differentially effect the risk of developing opioid use disorder (OUD). A cohort study was conducted to identify adult subjects (18–65 years old) with no previous history of OUD. Two cohorts were defined: subjects who we...
| Publicado en: | Journal of Substance Use Vol. 28; no. 1; pp. 101 - 112 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Feb2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161226670&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161226670 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14659891 ILV jtl: Journal of Substance Use issn: 14659891 maglogo: Y pubinfo: dt: Feb2023 vid: 28 iid: 1 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 161226670 161226670 161226670 10.1080/14659891.2021.2010140 161226670 ppf: 101 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Different classes of antibiotics have varying effects on the risk of developing opioid use disorder: a national database study. aug: au: Clegg, Taylor J. Kawmi, Noor Graziane, Nicholas M. affil: Doctor of Medicine Program, Penn State College of Medicine, Hershey, Pennsylvania, USA sug: subj: Antibiotics Therapeutic Use Substance Use Disorders Risk Factors Analgesics, Opioid Adverse Effects Risk Assessment Analgesics, Opioid Therapeutic Use Drug Therapy, Combination Human Prospective Studies Adult Middle Age Aged Inpatients Patient Discharge Emergency Service Cefepime Hydrochloride Adverse Effects Ertapenem Adverse Effects Doxycycline Adverse Effects Ceftriaxone Adverse Effects Sulfamethoxazole Adverse Effects Clindamycin Adverse Effects Azithromycin Adverse Effects Ciprofloxacin Adverse Effects Penicillins Adverse Effects Cefazolin Adverse Effects Amoxicillin Adverse Effects Retrospective Design Nonexperimental Studies Descriptive Statistics Confidence Intervals Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years ab: To examine whether different classes of antibiotics in combination with opioids differentially effect the risk of developing opioid use disorder (OUD). A cohort study was conducted to identify adult subjects (18–65 years old) with no previous history of OUD. Two cohorts were defined: subjects who were prescribed an opioid or an opioid in combination with antibiotics in the emergency department or inpatient unit, from the years 2015 to 2018. The diagnosis of an Opioid Related Disorder (F11.10-F11.20) 12 months following discharge from the emergency department or inpatient unit was then observed within the cohorts following the index event as identified by the ICD-10 procedural coding system. Primary analysis showed that penicillin G had no statistically significant effect, while the following list of antibiotics were associated with increased risk of developing OUD in order from highest to lowest risk: cefepime > tazobactam > ertapenem > doxycycline > ceftriaxone, sulfamethoxazole > clindamycin > azithromycin > ciprofloxacin > penicillins > cefazolin > amoxicillin > penicillin V. These findings suggest that the type of antibiotic prescribed in combination with opioid treatment may have important implications on the risk of developing OUD at later time points following hospital discharge. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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