Maximal Sensitivity to Child Maltreatment at the Ages of 6 and 11 Years is Associated with the Risk of Bipolar Disorder.
Adverse childhood experiences, including child maltreatment (CM), are relevant environmental risk factors for bipolar disorder (BD). However, little is known about the interaction of the type, duration and frequency of abuse with the timing of abuse in BD. The aim of this study was to investigate th...
| Published in: | Journal of Interpersonal Violence Vol. 38; no. 3/4; pp. 3030 - 3055 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
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Sage Publications Inc.
Feb2023
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| Subjects: | |
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=161364361&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 161364361 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 08862605 JIV jtl: Journal of Interpersonal Violence issn: 08862605 maglogo: Y pubinfo: dt: Feb2023 vid: 38 iid: 3/4 pid: 344 pub: Sage Publications Inc. artinfo: ui: 161364361 10.1177/08862605221106128 ppf: 3030 ppct: 25 formats: tig: atl: Maximal Sensitivity to Child Maltreatment at the Ages of 6 and 11 Years is Associated with the Risk of Bipolar Disorder. aug: au: Montoro, Irene Moreno, Lorena Mulet, Patricia Miró, Carlota Leunda, Ainhoa Llaurador-Coll, Martí Muntané, Gerard Teicher, Martin H. Vilella, Elisabet Gutiérrez-Zotes, Alfonso affil: Hospital Universitari Institut Pere Mata, Reus, Spain Institut d'Investigació Sanitària Pere Virgili, CERCA, Reus, Spain Universitat Rovira i Virgili, Reus, Spain Centro de Investigación Biomédica en Red en Salud Mental, CIBERSAM, Instituto de Salud Carlos III, Madrid, Spain Developmental Biopsychiatry Research Program, 24472 McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA su: Child abuse Age distribution Bipolar disorder Disease risk factors Random forest algorithms Risk assessment Research funding sug: subj: Child abuse Age distribution Bipolar disorder Disease risk factors Random forest algorithms Risk assessment Research funding keyword: bipolar disorder child abuse child maltreatment domestic violence MACE maltreatment chronology mental health and violence sensitive period timing bipolar disorder child abuse child maltreatment domestic violence MACE maltreatment chronology mental health and violence sensitive period timing ab: Adverse childhood experiences, including child maltreatment (CM), are relevant environmental risk factors for bipolar disorder (BD). However, little is known about the interaction of the type, duration and frequency of abuse with the timing of abuse in BD. The aim of this study was to investigate the different patterns of childhood trauma (frequency, type and chronology) between BD patients and healthy controls (HCs) and to identify BD-sensitive periods of exposure to CM that could influence functioning outcomes. The Maltreatment and Abuse Chronology Exposure (MACE) scale was used to evaluate the importance of the type and timing of maltreatment in a sample of 60 patients diagnosed with euthymic BD. Additionally, 76 HCs were recruited for comparison. All participants were of European-Caucasian origin and were assessed in the 2016-2019 period. To identify the variables that maximally differentiated the type and timing of exposure to CM between the BD and HC groups, a linear mixed effects model and random forest (RF) analyses were applied. We showed that multiplicity and severity, nonverbal emotional abuse, witnessing interparental violence and emotional neglect were the main factors associated with BD. In addition, regarding the occurrence of maltreatment in BD patients, we identified two sensitive periods with a principal peak at the age of 6 and a secondary peak at the age of 11. Functionality at the assessment time was associated with CM in adolescence for both HC and BD participants. Although the sample size and retrospective nature of the MACE instrument were the main limitations of our study, we were unable to explore the role of variables such as sex or socioeconomic status. We concluded that the multiplicity and sensitivity of CM exposure, mainly of the emotional type, during middle childhood are important risk factors for BD, at least in the European-Caucasian cultural setting. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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