Metabolomics of asthma, COPD, and asthma-COPD overlap: an overview.
The two common progressive lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are the leading causes of morbidity and mortality worldwide. Asthma-COPD overlap, referred to as ACO, is another complex pulmonary disease that manifests itself with features of both asthma and COPD. T...
| Publicado en: | Critical Reviews in Clinical Laboratory Sciences Vol. 60; no. 2; pp. 153 - 171 |
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| Autores principales: | , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161364849&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161364849 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10408363 1AV jtl: Critical Reviews in Clinical Laboratory Sciences issn: 10408363 maglogo: Y pubinfo: dt: Mar2023 vid: 60 iid: 2 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 161364849 160374425 161364849 161364849 10.1080/10408363.2022.2140329 161364849 ppf: 153 ppct: 18 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Metabolomics of asthma, COPD, and asthma-COPD overlap: an overview. aug: au: Dasgupta, Sanjukta Ghosh, Nilanjana Bhattacharyya, Parthasarathi Roy Chowdhury, Sushmita Chaudhury, Koel affil: School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, India sug: subj: Metabolomics Methods Asthma Diagnosis Pulmonary Disease, Chronic Obstructive Diagnosis Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Asthma Drug Therapy Pulmonary Disease, Chronic Obstructive Drug Therapy Asthma Metabolism Pulmonary Disease, Chronic Obstructive Metabolism Molecular Structure Magnetic Resonance Spectroscopy Quality Assessment Gas Chromatography-Mass Spectrometry Methods Lung Diseases Mortality Disease Management Biological Markers Morbidity Chromatography, Liquid Methods ab: The two common progressive lung diseases, asthma and chronic obstructive pulmonary disease (COPD), are the leading causes of morbidity and mortality worldwide. Asthma-COPD overlap, referred to as ACO, is another complex pulmonary disease that manifests itself with features of both asthma and COPD. The disease has no clear diagnostic or therapeutic guidelines, thereby making both diagnosis and treatment challenging. Though a number of studies on ACO have been documented, gaps in knowledge regarding the pathophysiologic mechanism of this disorder exist. Addressing this issue is an urgent need for improved diagnostic and therapeutic management of the disease. Metabolomics, an increasingly popular technique, reveals the pathogenesis of complex diseases and holds promise in biomarker discovery. This comprehensive narrative review, comprising 99 original research articles in the last five years (2017–2022), summarizes the scientific advances in terms of metabolic alterations in patients with asthma, COPD, and ACO. The analytical tools, nuclear magnetic resonance (NMR), gas chromatography-mass spectrometry (GC-MS), and liquid chromatography-mass spectrometry (LC-MS), commonly used to study the expression of the metabolome, are discussed. Challenges frequently encountered during metabolite identification and quality assessment are highlighted. Bridging the gap between phenotype and metabotype is envisioned in the future. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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