Development of Multi-target therapy for Alzheimer's disease using human neural crest-derived stem cells...International Society for Gerontechnology 13th World Conference, October 22-26, 2022, Daegu, South Korea
Purpose Stem cell transplantation is a promising therapeutic strategy for the treatment of many neurological disorders. The therapeutic effects, however, are sometimes inconsistent and unpredictable. Human neural crest- derived nasal turbinate stem cells (hNTSCs) are an excellent alternative source...
| Publicado en: | Gerontechnology Vol. 21; pp. 1 - 2 |
|---|---|
| Autores principales: | , , , , |
| Formato: | abstract proceedings research Journal Article |
| Publicado: |
International Society for Gerontechnology
Oct2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161396067&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161396067 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15691101 904R jtl: Gerontechnology issn: 15691101 maglogo: N pubinfo: dt: Oct2022 vid: 21 pid: 54298 pub: International Society for Gerontechnology artinfo: ui: 161396067 161396067 161396067 10.4017/gt.2022.21.s.822.sp3 161396067 ppf: 1 ppct: 1 formats: tig: atl: Development of Multi-target therapy for Alzheimer's disease using human neural crest-derived stem cells...International Society for Gerontechnology 13th World Conference, October 22-26, 2022, Daegu, South Korea aug: au: Lim, J. Y. Lee, J. E. Yang, S. H. Lim, H. K. Kim, S. W. affil: Department of Otolaryngology-Head and Neck Surgery, Seoul ST. Mary's Hospital, The Catholic University of Korea sug: subj: Hematopoietic Stem Cell Transplantation Methods Alzheimer's Disease Therapy Treatment Outcomes Human Congresses and Conferences South Korea South Korea ab: Purpose Stem cell transplantation is a promising therapeutic strategy for the treatment of many neurological disorders. The therapeutic effects, however, are sometimes inconsistent and unpredictable. Human neural crest- derived nasal turbinate stem cells (hNTSCs) are an excellent alternative source of adult stem cells for clinical use because they can be obtained easily by minimally invasive collection procedures and expanded rapidly ex vivo for transplantation. Moreover, the characteristics of hNTSCs, including their proliferation, differentiation, and immunophenotype, are not affected by donor age or passage number (Hwang et al., 2013), while other kinds of stem cells exhibit age and passage-related reduction in multiple characteristics. Method In the present study, we validated the hypothesis that hNTSCs are a clinically promising therapeutic source of adult stem cells for the treatment of Alzheimer's disease (AD). Here, we evaluated the tprotective effect of hNTSCs against amyloid-β peptide (Aβ1-42) neurotoxic activity in culture of human brain organoid (hBO). hNTSCs were evaluated in comparison with human bone marrow-derived mesenchymal stem cells (hBM-MSCs) according to the effect of transplantation on AD pathology, including PET/CT neuroimaging, immune status, and cognition, in a 5xFAD transgenic mouse model of AD. Results and Discussion Treatment of hBO with Aβ1-42 induced neuronal cell death concomitant with decreased expression of neuronal markers, which was suppressed by hNTSCs cocultured under Aβ1-42 exposure (Lim et al., 2022). Transplantation of hNTSCs greatly reduces the levels of Aβ42 and the number of microglia, concomitant with increased survival of hippocampal and cortex neurons when compared with transplantation of hBM-MSCs (Lim et al., 2021). Notably, compared with transplantation of hBM-MSCs, transplantation of hNTSCs significantly enhanced performance on the Morris water maze, with an increased level of TIMP2, which is necessary for spatial memory in young mice and neurons. These results reveal a promising therapeutic effect of hNTSCs and suggest a potential application of hNTSCs of future treatment for patients with AD. pubtype: Academic Journal doctype: abstract proceedings research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|