Impact of transcranial direct current stimulation on cognitive function, brain functional segregation, and integration in patients with mild cognitive impairment according to amyloid-beta deposition and APOE ε4-allele...International Society for Gerontechnology 13th World Conference, October 22-26, 2022, Daegu, South Korea
Purpose Anodal transcranial direct current stimulation (anodal-tDCS) is known to improve cognition (Liu, C.S., et al., 2017) and normalize abnormal network configuration during resting-state functional magnetic resonance imaging (fMRI) in patients with mild cognitive impairment (MCI) (Binnewijzend,...
| Published in: | Gerontechnology Vol. 21; pp. 1 - 2 |
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| Main Authors: | , , , , , , , |
| Format: | abstract proceedings research tables/charts Journal Article |
| Published: |
International Society for Gerontechnology
Oct2022
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161396068&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161396068 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15691101 904R jtl: Gerontechnology issn: 15691101 maglogo: N pubinfo: dt: Oct2022 vid: 21 pid: 54298 pub: International Society for Gerontechnology artinfo: ui: 161396068 161396068 161396068 161396068 ppf: 1 ppct: 1 formats: tig: atl: Impact of transcranial direct current stimulation on cognitive function, brain functional segregation, and integration in patients with mild cognitive impairment according to amyloid-beta deposition and APOE ε4-allele...International Society for Gerontechnology 13th World Conference, October 22-26, 2022, Daegu, South Korea aug: au: Kang, D. W. Wang, S.-M. Kim, T. Y. Kim, D. H. Na, H.-R. Kim, N.-Y. Lee, C. U. Lim, H. K. affil: Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea sug: subj: Transcranial Direct Current Stimulation Methods Cognition Evaluation Brain Physiopathology Patient Care Mild Cognitive Impairment Plaque, Amyloid Apolipoproteins Alleles Congresses and Conferences South Korea South Korea ab: Purpose Anodal transcranial direct current stimulation (anodal-tDCS) is known to improve cognition (Liu, C.S., et al., 2017) and normalize abnormal network configuration during resting-state functional magnetic resonance imaging (fMRI) in patients with mild cognitive impairment (MCI) (Binnewijzend, M.A., et al., 2012). We aimed to evaluate the impact of sequential anodal-tDCS on cognitive functions, functional segregation, and integration parameters in patients with MCI, according to high-risk factors for Alzheimer's disease (AD): amyloid-beta (Aβ) deposition and APOE ε4-allele status. Method In 32 patients with MCI ([18F] flutemetamol-: n = 10, [18F] flutemetamol+: n = 22; APOE ε4-: n = 13, APOE ε4+: n = 19), we delivered anodal-tDCS (2 mA/day, five times/week, for 2 weeks) over the left dorsolateral prefrontal cortex and assessed the neuropsychological test battery and resting-state fMRI measurements before and after 2 weeks' stimulation. Results and Discussion We observed a non-significant impact of an anodal-tDCS on changes in neuropsychological battery scores between MCI patients with and without high-risk factors of AD, Aβ retention and APOE ε4-allele. However, there was a significant difference in brain functional segregation and integration parameters between MCI patients with and without AD high-risk factors. We also found a significant effect of tDCS-by-APOE ε4-allele interaction on changes in the functional segregation parameter of the temporal pole. In addition, baseline Aβ deposition significantly associated negatively with change in global functional integrity of hippocampal formation. Anodal-tDCS might help to enhance restorative and compensatory intrinsic functional changes in MCI patients, modulated by the presence of Aβ retention and the APOE ε4-allele. pubtype: Academic Journal doctype: abstract proceedings research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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