123I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation.
Purpose: Heart failure (HF) is a primary cause of morbidity and mortality worldwide, with significant impact on life quality and extensive healthcare costs. Assessment of myocardial sympathetic innervation function plays a central role in prognosis assessment in HF patients. The aim of this review i...
| Published in: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 50; no. 3; pp. 813 - 825 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Feb2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161397708&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161397708 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Feb2023 vid: 50 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161397708 10.1007/s00259-022-05941-3 161397708 ppf: 813 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: 123I-MIBG imaging in heart failure: impact of comorbidities on cardiac sympathetic innervation. aug: au: Gargiulo, Paola Acampa, Wanda Asile, Gaetano Abbate, Vincenza Nardi, Ermanno Marzano, Federica Assante, Roberta Nappi, Carmela Parlati, Antonio Luca Maria Basile, Christian Dellegrottaglie, Santo Paolillo, Stefania Cuocolo, Alberto Perrone-Filardi, Pasquale affil: Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy sug: ab: Purpose: Heart failure (HF) is a primary cause of morbidity and mortality worldwide, with significant impact on life quality and extensive healthcare costs. Assessment of myocardial sympathetic innervation function plays a central role in prognosis assessment in HF patients. The aim of this review is to summarize the most recent evidence regarding the clinical applications of iodine-123 metaiodobenzylguanidine (123I-MIBG) imaging in patients with HF and related comorbidities. Methods: A comprehensive literature search was conducted on PubMed and Web of Science databases. Articles describing the impact of 123I-MIBG imaging on HF and related comorbidities were considered eligible for the review. Results: We collected several data reporting that 123I-MIBG imaging is a safe and non-invasive tool to evaluate dysfunction of cardiac sympathetic neuronal function and to assess risk stratification in HF patients. HF is frequently associated with comorbidities that may affect cardiac adrenergic innervation. Furthermore, HF is frequently associated with comorbidities and chronic conditions, such as diabetes, obesity, kidney disease and others, that may affect cardiac adrenergic innervation. Conclusion: Comorbidities and chronic conditions lead to more severe impairment of sympathetic nervous system in patients with HF, with a negative impact on disease progression and outcome. Cardiac imaging with 123I-MIBG can be a useful tool to reduce morbidity and prevent adverse events in HF patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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