Aberrant intrinsic functional brain networks in patients with functional constipation.
Purpose: Patients with functional constipation (FCon) often suffer from mental and psychological problems. To explore the possible neurological interaction, we used resting-state functional magnetic imaging (RS-fMRI) to compare the alterations in intrinsic brain functional networks at multiple level...
| Publicado en: | Neuroradiology Vol. 65; no. 2; pp. 337 - 349 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2023
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161418603&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161418603 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Feb2023 vid: 65 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161418603 159574700 161418603 161418603 10.1007/s00234-022-03064-y 161418603 ppf: 337 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Aberrant intrinsic functional brain networks in patients with functional constipation. aug: au: Yu, Xiang Yu, Jingjie Li, Yuwei Cong, Jiying Wang, Chao Fan, Ran Wang, Wanbing Zhou, Lige Xu, Chen Li, Yiming Liu, Yawu affil: Department of Radiology, Tianjin Union Medical Center, No. 190, Jieyuan Road, 300121, Hongqiao District, Tianjin, China sug: subj: Constipation Complications Functional Connectivity Evaluation Magnetic Resonance Imaging Methods Neuroradiography Human Comparative Studies Neuropsychological Tests Emotions Brain-Gut Axis Descriptive Statistics Funding Source ab: Purpose: Patients with functional constipation (FCon) often suffer from mental and psychological problems. To explore the possible neurological interaction, we used resting-state functional magnetic imaging (RS-fMRI) to compare the alterations in intrinsic brain functional networks at multiple levels between patients with FCon and healthy controls (HC). Methods: Twenty-eight patients with FCon and twenty-nine HC were recruited for a series of examinations and RS-fMRI. Both graph theory analysis and functional connectivity (FC) analysis were used to investigate brain functional alterations between the two groups. Correlation analyses were performed among neuropsychological scores, clinical indexes, and neuroimaging data. Results: Compared with the HC, the assortativity showed significantly increased in global level in patients with FCon. In regional level, we found obviously increased nodal degree and nodal efficiency in somatosensory network (SMN), decreased nodal degree, and increased nodal efficiency in default mode network (DMN) in the FCon group. Furthermore, FC analysis demonstrated several functional alterations within and between the networks, particularly including the SMN and visual network (VN) in sub-network and large-scale network analysis. Moreover, correlation analysis indicated that nodal metrics and aberrant FC among functional brain networks were associated with emotion and scores of constipation in patients with FCon. Conclusion: All these findings reflect the differences in intrinsic brain functional networks between FCon and HC. Our study highlighted SMN, DMN, and VN as critical network and may be involved in the neurophysiology of FCon, which may contribute to improve personalized treatment in patients with FCon. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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