Skin Infections Due to Panton-Valentine Leukocidin-Producing S. Aureus.
Background: Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus (PVL-SA) strains are frequently associated with large, recurring abscesses in otherwise healthy young individuals. The typical clinical presentation and the recommended diagnostic evaluation and treatment are not widely kn...
| Publicado en: | Deutsches Ärzteblatt International Vol. 119; no. 45; pp. 775 - 785 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Deutscher Aerzte-Verlag GmbH
11/11/2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161512139&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161512139 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18660452 5F0N jtl: Deutsches Ärzteblatt International issn: 18660452 maglogo: N pubinfo: dt: 11/11/2022 vid: 119 iid: 45 pid: 25312 pub: Deutscher Aerzte-Verlag GmbH artinfo: ui: 161512139 10.3238/arztebl.m2022.0308 161512139 ppf: 775 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Skin Infections Due to Panton-Valentine Leukocidin-Producing S. Aureus. aug: au: Leistner, Rasmus Hanitsch, Leif G. Krüger, Renate Lindner, Andreas K. Stegemann, Miriam S. Nurjadi, Dennis affil: Division of Gastroenteralogy, Infectious Diseases and Rheumatology, Charite - Universitätsmedizin Berlin, Freie Universität Berlin und Humboldt-Universität zu Berlin sug: ab: Background: Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus (PVL-SA) strains are frequently associated with large, recurring abscesses in otherwise healthy young individuals. The typical clinical presentation and the recommended diagnostic evaluation and treatment are not widely known. Methods: This review is based on pertinent publications retrieved by a selective search in PubMed, with special attention to international recommendations. Results: PVL-SA can cause leukocytolysis and dermatonecrosis through specific cell-wall pore formation. Unlike other types of pyoderma, such conditions caused by PVL-SA have no particular site of predilection. In Germany, the PVL gene can be detected in 61.3% (252/411) of skin and soft tissue infections with S. aureus. Skin and soft tissue infections with PVL-SA recur three times as frequently as those due to PVL-negative S. aureus. They are diagnosed by S. aureus culture from wound swabs and combined nasal/pharyngeal swabs, along with PCR for gene detection. The acute treatment of the skin abscesses consists of drainage, followed by antimicrobial therapy if needed. Important secondary preventive measures include topical cleansing with mupirocin nasal ointment and whole-body washing with chlorhexidine or octenidine. The limited evidence (level lib) concerning PVL-SA is mainly derived from nonrandomized cohort studies and experimental analyses. Conclusion: PVL-SA skin infections are easily distinguished from other skin diseases with targeted history-taking and diagnostic evaluation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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