Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder.
Rationale: Brain iron accumulation has been observed in neuropsychiatric disorders and shown to be related to neurodegeneration. Objectives: In this study, we used quantitative susceptibility mapping (QSM), an emerging MRI technique developed for quantifying tissue magnetic susceptibility, to examin...
| Published in: | Psychopharmacology Vol. 240; no. 2; pp. 249 - 258 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Feb2023
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161515379&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161515379 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Feb2023 vid: 240 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 161515379 161032133 10.1007/s00213-022-06301-7 161515379 ppf: 249 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorder. aug: au: Tan, Haoye Hubertus, Simon Thomas, Sebastian Lee, Alycia M. Gerhardt, Sarah Gerchen, Martin Fungisai Sommer, Wolfgang H. Kiefer, Falk Schad, Lothar Vollstädt-Klein, Sabine affil: Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty of Mannheim, Heidelberg University, 68159, Mannheim, Germany sug: ab: Rationale: Brain iron accumulation has been observed in neuropsychiatric disorders and shown to be related to neurodegeneration. Objectives: In this study, we used quantitative susceptibility mapping (QSM), an emerging MRI technique developed for quantifying tissue magnetic susceptibility, to examine brain iron accumulation in individuals with alcohol use disorder (AUD) and its relation to compulsive drinking. Methods: Based on our previous projects, QSM was performed as a secondary analysis with gradient echo sequence images, in 186 individuals with AUD and 274 healthy participants. Whole-brain susceptibility values were calculated with morphology-enabled dipole inversion and referenced to the cerebrospinal fluid. Then, the susceptibility maps were compared between AUD individuals and healthy participants. The relationship between drinking patterns and susceptibility was explored. Results: Whole-brain analyses showed that the susceptibility in the dorsal striatum (putamen and caudate) among AUD individuals was higher than healthy participants and was positively related to the Obsessive Compulsive Drinking Scale (OCDS) scores and the amount of drinking in the past three months. Conclusions: Increased susceptibility suggests higher iron accumulation in the dorsal striatum in AUD. This surrogate for the brain iron level was linearly associated with the compulsive drinking pattern and the recent amount of drinking, which provides us a new clinical perspective in relation to brain iron accumulation, and also might indicate an association of AUD with neuroinflammation as a consequence of brain iron accumulation. The iron accumulation in the striatum is further relevant for functional imaging studies in AUD by potentially producing signal dropout and artefacts in fMRI images. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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