Relationships Between Histopathological Findings in the Liver and Prognosis in Patients With Biliary Atresia.
BACKGROUND: Biliary atresia (BA) is a progressive obstructive hepatic disease that requires early diagnosis and the prompt initiation of treatment. Although portoenterostomy (PES) is usually performed as the initial surgical procedure, the liver damage may subsequently progress, such that liver tran...
| Publicado en: | Clinical Pathology Vol. 15; pp. 1 - 9 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jan-Dec2022
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161572542&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161572542 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2632010X M8A9 jtl: Clinical Pathology issn: 2632010X maglogo: Y pubinfo: dt: Jan-Dec2022 vid: 15 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 161572542 161572542 161572542 10.1177/2632010X221132686 161572542 ppf: 1 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Relationships Between Histopathological Findings in the Liver and Prognosis in Patients With Biliary Atresia. aug: au: Atsushi Higashio Takako Yoshioka Yutaka Kanamori Akihiro Fujino Yoshiki Morotomi Toshihiko Shibata Tatsuo Nakaoka affil: Department of Surgery, Osaka Metropolitan University School of Medicine, Osaka, Japan sug: subj: Liver Pathology Biliary Atresia Prognosis Histocytochemistry Human Retrospective Design Biopsy Quantitative Studies HLA Antigens Descriptive Statistics Multivariate Analysis Correlational Studies Survival Analysis Graft Versus Host Disease Male Female Male Female ab: BACKGROUND: Biliary atresia (BA) is a progressive obstructive hepatic disease that requires early diagnosis and the prompt initiation of treatment. Although portoenterostomy (PES) is usually performed as the initial surgical procedure, the liver damage may subsequently progress, such that liver transplantation (LTx) may be required. In this study, we comprehensively evaluated the histopathology of liver samples collected during PES and retrospectively evaluated its relationship with prognosis. METHODS: Forty-seven patients with BA who underwent PES between 2002 and 2021 were included. Their biopsy samples were semiquantitatively graded according to the severity of liver fibrosis, bile duct proliferation, cholestasis, ductal plate malformation, and inflammatory cell infiltration; and the expression of cluster of differentiation (CD)3, CD20, human leukocyte antigen II-DR, and a-smooth muscle actin (a-SMA). The relationships of each with the prevalence of survival with native liver (SNL) were evaluated to identify prognostic markers. RESULTS: The median postoperative duration of follow-up was 11.8 years (maximum, 18.0 years; minimum, 3.5 years). There were no deaths during this period, but LTx was performed in 31 patients and the final prevalence of SNL was 34.0% (16/47). There were negative correlations of liver fibrosis and a-SMA with SNL, and a positive correlation between CD20 and SNL. Multivariate analysis using a proportional hazards regression model showed that only CD20 expression was significant. CONCLUSIONS: Comprehensive histopathological analysis of liver biopsy samples obtained at the time of PES showed a positive correlation between CD20 expression and SNL, suggesting that this may represent a useful prognostic marker. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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