Choroidal thickness in patients with systemic arterial hypertension: a systematic review and meta-analysis.
Background: The global burden of hypertension is constantly increasing with adverse cardiovascular and ocular sequelae. The association between elevated blood pressure and choroidal thickness (CT), as assessed via optical coherence tomography (OCT), is poorly understood. Objectives and Design: Studi...
| Publicado en: | Therapeutic Advances in Ophthalmology Vol. 14; pp. 1 - 10 |
|---|---|
| Autores principales: | , , , , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Sage Publications Inc.
Jan-Dec2022
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=161641770&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 161641770 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 25158414 LAW0 jtl: Therapeutic Advances in Ophthalmology issn: 25158414 maglogo: Y pubinfo: dt: Jan-Dec2022 vid: 14 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 161641770 161641770 161641770 10.1177/25158414221132825 161641770 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Choroidal thickness in patients with systemic arterial hypertension: a systematic review and meta-analysis. aug: au: Papathanasiou, Konstantinos A. Kazantzis, Dimitrios Vrachatis, Dimitrios A. Giotaki, Sotiria G. Papaconstantinou, Eva Kanakis, Menelaos Avramides, Dimitrios Deftereos, Spyridon Chatziralli, Irini Georgalas, Ilias affil: Medical School, National and Kapodistrian University of Athens, Athens, Greece sug: subj: Uvea Pathology Hypertension Complications Human Tomography, Optical Coherence Adult Medline Cochrane Library Systematic Review Meta Analysis Adult: 19-44 years ab: Background: The global burden of hypertension is constantly increasing with adverse cardiovascular and ocular sequelae. The association between elevated blood pressure and choroidal thickness (CT), as assessed via optical coherence tomography (OCT), is poorly understood. Objectives and Design: Studies including hypertensive adults and normotensive controls undergoing OCT were evaluated for inclusion in this meta-analysis. The primary endpoint was CT difference between hypertensive and normotensive adults. Data Sources and Methods: We conducted a systematic review and after searching 1011 results from MEDLINE, ClinicalTrials.gov, medRxiv and Cochrane Library, six studies were deemed eligible and were pooled according to a random-effect model. Results: A statistically significant reduction in choroidal thickness was found in hypertensive adults (n = 454) as compared with normotensive controls (n = 365) [mean difference: -0.77; 95% confidence intervals: (-1.20, -0.34); p = 0.0004]. The main limitations of this meta-analysis are the relatively small population included and the high statistical heterogeneity (I2 = 87%) among the various studies. Of note, after excluding one study the heterogeneity was markedly reduced. Conclusion: Choroidal thickness is reduced among hypertensive subjects compared with normotensive controls. This finding mandates further examination in the context of long-term clinical outcomes. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|